The indispensable roles of microglia and astrocytes during brain development

K Reemst, SC Noctor, PJ Lucassen… - Frontiers in human …, 2016 - frontiersin.org
Glia are essential for brain functioning during development and in the adult brain. Here, we
discuss the various roles of both microglia and astrocytes, and their interactions during brain …

Monocytes and macrophages: developmental pathways and tissue homeostasis

F Ginhoux, S Jung - Nature Reviews Immunology, 2014 - nature.com
Monocytes and macrophages have crucial and distinct roles in tissue homeostasis and
immunity, but they also contribute to a broad spectrum of pathologies and are thus attractive …

Origin of microglia: current concepts and past controversies

F Ginhoux, M Prinz - Cold Spring Harbor perspectives in …, 2015 - cshperspectives.cshlp.org
Microglia are the resident macrophages of the central nervous system (CNS), which sit in
close proximity to neural structures and are intimately involved in brain homeostasis. The …

Origin and differentiation of microglia

F Ginhoux, S Lim, G Hoeffel, D Low… - Frontiers in cellular …, 2013 - frontiersin.org
Microglia are the resident macrophage population of the central nervous system (CNS).
Adequate microglial function is crucial for a healthy CNS. Microglia are not only the first …

Fate map** analysis reveals that adult microglia derive from primitive macrophages

F Ginhoux, M Greter, M Leboeuf, S Nandi, P See… - Science, 2010 - science.org
Microglia are the resident macrophages of the central nervous system and are associated
with the pathogenesis of many neurodegenerative and brain inflammatory diseases; …

Adult Langerhans cells derive predominantly from embryonic fetal liver monocytes with a minor contribution of yolk sac–derived macrophages

G Hoeffel, Y Wang, M Greter, P See, P Teo… - Journal of Experimental …, 2012 - rupress.org
Langerhans cells (LCs) are the dendritic cells (DCs) of the epidermis, forming one of the first
hematopoietic lines of defense against skin pathogens. In contrast to other DCs, LCs arise …

Vitamin D and human health: lessons from vitamin D receptor null mice

R Bouillon, G Carmeliet, L Verlinden… - Endocrine …, 2008 - academic.oup.com
The vitamin D endocrine system is essential for calcium and bone homeostasis. The precise
mode of action and the full spectrum of activities of the vitamin D hormone, 1, 25 …

A Coupled SYSTEM of Intracellular Ca2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekee** Mechanism of the Heart's Pacemaker

EG Lakatta, VA Maltsev, TM Vinogradova - Circulation research, 2010 - ahajournals.org
Ion channels on the surface membrane of sinoatrial nodal pacemaker cells (SANCs) are the
proximal cause of an action potential. Each individual channel type has been thoroughly …

Calcium absorption across epithelia

JGJ Hoenderop, B Nilius… - Physiological …, 2005 - journals.physiology.org
Ca2+ is an essential ion in all organisms, where it plays a crucial role in processes ranging
from the formation and maintenance of the skeleton to the temporal and spatial regulation of …

Biomechanical forces promote embryonic haematopoiesis

L Adamo, O Naveiras, PL Wenzel… - Nature, 2009 - nature.com
Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in
the develo** cardiovascular system,. After initiation of the heartbeat in vertebrates, cells …