Novel histopathological biomarkers in prostate cancer: implications and perspectives
P Kiełb, K Kowalczyk, A Gurwin, Ł Nowak, W Krajewski… - Biomedicines, 2023 - mdpi.com
Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. Despite the
significant progress in cancer diagnosis and treatment over the last few years, the approach …
significant progress in cancer diagnosis and treatment over the last few years, the approach …
[HTML][HTML] Exploring the role of sporadic BRAF and KRAS mutations during colorectal cancer pathogenesis: A spotlight on the contribution of the endosome-lysosome …
The highly heterogenous nature of colorectal cancer can significantly hinder its early and
accurate diagnosis, eventually contributing to high mortality rates. The adenoma-carcinoma …
accurate diagnosis, eventually contributing to high mortality rates. The adenoma-carcinoma …
Altered expression of vesicular trafficking machinery in prostate cancer affects lysosomal dynamics and provides insight into the underlying biology and disease …
Background This study focuses on the role of lysosomal trafficking in prostate cancer, given
the essential role of lysosomes in cellular homoeostasis. Methods Lysosomal motility was …
the essential role of lysosomes in cellular homoeostasis. Methods Lysosomal motility was …
Dynamic interplay between sortilin and syndecan-1 contributes to prostate cancer progression
J Lazniewska, KL Li, IRD Johnson, A Sorvina… - Scientific reports, 2023 - nature.com
Prostate cancer (PCa) development and progression relies on the programming of glucose
and lipid metabolism, and this involves alterations in androgen receptor expression and …
and lipid metabolism, and this involves alterations in androgen receptor expression and …
Prediction of prostate cancer biochemical and clinical recurrence is improved by IHC-assisted grading using Appl1, Sortilin and Syndecan-1
Simple Summary A novel biomarker panel (Appl1, Sortilin and Syndecan-1) was
demonstrated as a strong independent predictor for both clinical and biochemical …
demonstrated as a strong independent predictor for both clinical and biochemical …
Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers
The diagnosis of prostate cancer using histopathology is reliant on the accurate
interpretation of prostate tissue sections. Current standards rely on the assessment of …
interpretation of prostate tissue sections. Current standards rely on the assessment of …
[HTML][HTML] Altered endosomal-lysosomal biogenesis in melanoma
Cutaneous melanoma is the deadliest form of skin neoplasm and its high mortality rates
could be averted by early accurate detection. While the detection of melanoma is currently …
could be averted by early accurate detection. While the detection of melanoma is currently …
Insights into melanoma clinical practice: a perspective for future research
Simple Summary This study acknowledges the challenges in melanoma diagnosis and the
need for new technology that aids clinical decision making. Biomarkers that can accurately …
need for new technology that aids clinical decision making. Biomarkers that can accurately …
Intracellular osteopontin promotes the release of TNFα by mast cells to restrain neuroendocrine prostate cancer
Neuroendocrine prostate cancer (NEPC) is an aggressive form of prostate cancer that
emerges as tumors become resistant to hormone therapies or, rarely, arises de novo in …
emerges as tumors become resistant to hormone therapies or, rarely, arises de novo in …
[HTML][HTML] Appl1, Sortilin and Syndecan-1 immunohistochemistry on intraductal carcinoma of the prostate provides evidence of retrograde spread
The presence of intraductal carcinoma of the prostate (IDCP) correlates with late-stage
disease and poor outcomes for patients with prostatic adenocarcinoma, but the accurate and …
disease and poor outcomes for patients with prostatic adenocarcinoma, but the accurate and …