Develo** drugs for the central nervous system (CNS) requires fine chemical modifications,
as a strict balance between size and lipophilicity is necessary to improve the permeability …

Targeting tyrosinase (TYR), a key enzyme responsible for melanogenesis disorders, is a
well-known approach utilized for the development of melanogenesis inhibitor. A variety of …

A small library of flavone-based hydrazones has been designed, synthesized and
characterized. In this context, thirteen flavone hydrazones (3a-3 m) were synthesized by the …

Selected N-benzoylated piperazine compounds were synthesized to study their
conformational behavior using temperature-dependent 1H NMR spectroscopy. All …

In this study; molecular structure, IR and NMR spectroscopic properties of (E)-2‑methoxy-4-
(2-morpholinovinyl) phenol are investigated both experimentally and theoretically for the first …

Novel, functionalized piperazine derivatives were successfully synthesized and fully
characterized by 1 H/13 C/19 F NMR, MS, elemental analysis and lipophilicity. All piperazine …

The fluorinated chalcones were synthesized by Claisen-Schmidt condensation between 4′-
morpholineacetophenone and various fluorinated benzaldehydes in the presence of NaOH …

Introduction Chalcone compounds exhibit diverse bioactivities, attracting significant interest.
Morpholine is a heterocycle commonly used in medicinal chemistry. It could enhance the …

A series of thirteen (2E)-1-[4-({6-nitro-2-[(E)-2-phenylvinyl] quinolin-4-yl} amino) phenyl]-3-
[(substituted) phenyl] prop-2-en-1-ones (5a-5m) were synthesized by five-step synthesis …

A new water-soluble multidentate ligand based on a second-generation hyperbranched
polyester containing 3-(morpholin-4-yl) propionate fragments in the terminal position has …