Leishmaniasis, a neglected parasitic disease caused by a unicellular protozoan of the
genus Leishmania, is transmitted through the bite of a female sandfly. The disease remains …

The production of nitric oxide (NO) by the inducible NO synthase (iNOS) is a key defense
mechanism against intracellular pathogens such as Leishmania. Numerous studies have …

Leishmaniasis is a neglected infectious disease with clinical presentations ranging from
asymptomatic or mild symptoms to chronic infection and eventual death. The mechanisms of …

In American Tegumentary Leishmaniasis production of cytokines, reactive oxygen species
and nitric oxide (NO) by host macrophages normally lead to parasite death. However, some …

Verbascoside is the main component of the traditional medicinal plants that were used
against protozoa parasites that cause malaria and leishmaniasis. Previously, we have …

Understanding the mechanism (s) underpinning drug resistance could lead to novel
treatments to reverse the increased tolerance of a pathogen. In this study, paromomycin …

Arginase (Arg) 1 is expressed by hematopoietic (eg, macrophages) and nonhematopoietic
cells (eg, endothelial cells) and converts l-arginine into ornithine and urea. The enzyme is …

Background Visceral Leishmaniasis (VL) is the most severe form of leishmaniasis because it
can lead to death. In the Americas, 96% of cases are in Brazil, and despite efforts, the fatality …

Leishmania tropica causes different forms of leishmaniasis in many parts of the world.
Animal models can help to clarify the issues of pathology and immune response in L. tropica …

Background Cutaneous leishmaniasis (CL) is a vector-borne parasitic disease caused by
protozoa of the genus Leishmania. In Morocco, CL is a public health problem mainly caused …