Continuous cell programming devices
DJ Mooney, O Ali, G Dranoff - US Patent 10,328,133, 2019 - Google Patents
All et al.“Sustained GM-CSF and PEI Condensed pDNA Presen tation Increases the Level
and Duration of Gene Expression in Dendritic Cells.” J. Control. Release. 132. 3 (2008): 273 …
and Duration of Gene Expression in Dendritic Cells.” J. Control. Release. 132. 3 (2008): 273 …
In situ antigen-generating cancer vaccine
The invention represents a significant breakthrough in the treatment of cancer in that tumor
antigens for vaccination are generated without having to take a biopsy from the patient …
antigens for vaccination are generated without having to take a biopsy from the patient …
Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration
BACKGROUND Tissue engineering is an approach for regeneration, replacement, and
improvement of the functions of damaged tissues by manipulating materials according to the …
improvement of the functions of damaged tissues by manipulating materials according to the …
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
Aspects of the invention relate to spherical nucleic acid based constructs and related
methods and compositions thereof. The compositions of the invention are useful for …
methods and compositions thereof. The compositions of the invention are useful for …
Programming of cells for tolerogenic therapies
RW Sands, EAB e Silva, T Kawai… - US Patent 9,381,235, 2016 - Google Patents
Biomaterial systems, eg, gel scaffolds, are used in vivo to recruit immune cells and promote
their activation towards a non-inflammatory phenotype, thereby leading Suppression of …
their activation towards a non-inflammatory phenotype, thereby leading Suppression of …
Scaffolds for cell collection or elimination
DJ Mooney - US Patent 9,770,535, 2017 - Google Patents
5, 132, 405 A 7/1992 Huston et al. 5, 885, 829 A 3/1999 Mooney et al. 5, 888, 987 A 3/1999
Haynes et al. 6, 129, 716 A 10/2000 Steer 6, 193, 970 B1 2/2001 Pardoll et al. 6, 251, 396 …
Haynes et al. 6, 129, 716 A 10/2000 Steer 6, 193, 970 B1 2/2001 Pardoll et al. 6, 251, 396 …
Controlled release of growth factors and signaling molecules for promoting angiogenesis
L Cao, DJ Mooney - US Patent 9,012,399, 2015 - Google Patents
The present invention comprises compositions, methods, and devices for delivering
angiogenic factors and signaling mol ecules to a target tissue, and controlling the release of …
angiogenic factors and signaling mol ecules to a target tissue, and controlling the release of …
Scaffolds for cell transplantation
A device that includes a scaffold composition and a bioactive composition with the bioactive
composition being incorporated into or coated onto the scaffold composition such that the …
composition being incorporated into or coated onto the scaffold composition such that the …
Enhancement of skeletal muscle stem cell engraftment by dual delivery of vegf and igf-1
DJ Mooney, C Borselli, H Vandenburgh… - US Patent …, 2017 - Google Patents
2013-07-05 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones
2003/0100527 A1 5/2003 2003/0232895 A1 12, 2003 2004/0058883 A1 3, 2004
2004/006.3206 A1 4, 2004 2004/O136968 A1 T/2004 2004/O151764 A1 8, 2004 …
2004/006.3206 A1 4, 2004 2004/O136968 A1 T/2004 2004/O151764 A1 8, 2004 …