The persistence of latent reservoir of the human immunodeficiency virus (HIV) is currently
the major challenge in curing HIV infection. After HIV infects the human body, the latent HIV …

Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to
global public health. Despite advances in antiretroviral therapy (ART), which has …

Quantifying the replication-competent HIV reservoir is essential for evaluating curative
strategies. Viral outgrowth assays (VOAs) underestimate the reservoir because they fail to …

BACKGROUND Identifying factors that predict the timing of HIV rebound after treatment
interruption will be crucial for designing and evaluating interventions for HIV remission …

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Persistence of HIV in people living with HIV (PWH) on suppressive antiretroviral therapy
(ART) has been linked to physiological mechanisms of CD4+ T cells. Here, in the same 37 …

Antiretroviral therapy controls HIV replication but does not eliminate the virus from the
infected host. The persistence of a small pool of cells harboring integrated and replication …

A cure for HIV infection remains elusive due to the persistence of replication-competent HIV
proviral DNA during suppressive antiretroviral therapy (ART). With the exception of rare elite …

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral
therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations …

The persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is
a major barrier to an HIV/SIV cure. These reservoirs are predominately contained within …