Loss of normal kidney function affects more than 10% of the population and contributes to
morbidity and mortality. Kidney diseases are currently treated with immunosuppressive …

Twenty-five years ago, the first mammalian Transient Receptor Potential Canonical (TRPC)
channel was cloned, opening the vast horizon of the TRPC field. Today, we know that there …

Gene therapy for kidney diseases has proven challenging. Adeno-associated virus (AAV) is
used as a vector for gene therapy targeting other organs, with particular success …

Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents
filtration of large proteins and macromolecules into the urine. Podocyte function is …

An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …

The mechanical environment of cardiac cells changes continuously and undergoes major
alterations during diseases. Most cardiac diseases, including atrial fibrillation, are …

Dysfunction of slit diaphragm, a cell–cell junction of glomerular podocytes, is involved in the
development of proteinuria in several glomerular diseases. Slit diaphragm should be a …

Background Diabetic kidney disease is associated with impaired podocyte autophagy and
subsequent podocyte injury. The regulation of podocyte autophagy is unique because it …

Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential
cation channel, subfamily C, member 6) were linked to development of familial forms of …