Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …

The AMPK (AMP-activated protein kinase) and TOR (target-of-rapamycin) pathways are
interlinked, opposing signaling pathways involved in sensing availability of nutrients and …

Since the discovery of AMP-activated protein kinase (AMPK) as a central regulator of energy
homeostasis, many exciting insights into its structure, regulation and physiological roles …

Cells constantly adapt their metabolism to meet their energy needs and respond to nutrient
availability. Eukaryotes have evolved a very sophisticated system to sense low cellular ATP …

Mammalian AMPK is known to be activated by falling cellular energy status, signaled by
rising AMP/ATP and ADP/ATP ratios. We review recent information about how this occurs …

The liver is crucial for the maintenance of normal glucose homeostasis—it produces glucose
during fasting and stores glucose postprandially. However, these hepatic processes are …

AMP-activated protein kinase (AMPK) is a key regulator of energy balance expressed
ubiquitously in eukaryotic cells. Here we review the canonical adenine nucleotide …

The 5′-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a natural
energy sensor in mammalian cells that plays a key role in cellular and systemic energy …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy and nutrient status,
expressed almost universally in eukaryotes as heterotrimeric complexes comprising catalytic …

The AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that is
expressed in essentially all eukaryotic cells, suggesting that it arose during early eukaryotic …