ATP-binding cassette (ABC) transporters mediate the ATP-driven translocation of structurally
and mechanistically distinct substrates against steep concentration gradients. Among the …

ATP-binding cassette (ABC) transporters represent one of the largest and oldest families of
membrane proteins in all extant phyla from prokaryotes to humans, which couple the energy …

▪ Abstract The ATP-binding cassette (ABC) transporters are a family of large proteins in
membranes and are able to transport a variety of compounds through membranes against …

Paclitaxel (Taxol®) is a member of the taxane class of anticancer drugs and one of the most
common chemotherapeutic agents used against many forms of cancer. Paclitaxel is a …

This article provides an overview of the patient‐specific and drug‐specific variables that can
affect drug absorption following oral product administration. The oral absorption of any …

Multidrug Resistance Proteins (MRPs), together with the cystic fibrosis conductance
regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) …

One of the major problems related with anticancer chemotherapy is resistance against
anticancer drugs. The ATP-binding cassette (ABC) transporters are a family of transporter …

The antioxidant glutathione (GSH) is essential for the cellular detoxification of reactive
oxygen species in brain cells. A compromised GSH system in the brain has been connected …

This review summarizes current knowledge on glutathione (GSH) associated cellular
processes that play a central role in defense against oxidative stress. GSH itself is a critical …

Many orally administered drugs must overcome several barriers before reaching their target
site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic …