Polymerization of actin filaments against membranes produces force for numerous cellular
processes, such as migration, morphogenesis, endocytosis, phagocytosis and organelle …

Cytoplasmic dynein 1 is an important microtubule-based motor in many eukaryotic cells.
Dynein has critical roles both in interphase and during cell division. Here, we focus on …

Cytoplasmic dynein is a microtubule motor that is activated by its cofactor dynactin and a
coiled-coil cargo adaptor,–. Up to two dynein dimers can be recruited per dynactin, and …

Cytoplasmic dynein is a microtubule motor vital for cellular organization and division. It
functions as a~ 4-megadalton complex containing its cofactor dynactin and a cargo-specific …

Accurate estimation of the contrast transfer function (CTF) is critical for a near-atomic
resolution cryo electron microscopy (cryoEM) reconstruction. Here, a GPU-accelerated …

Organisms from all domains of life depend on filaments of the protein actin to provide
structure and to support internal movements. Many eukaryotic cells use forces produced by …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

Arp2/3 complex is an actin filament nucleation and branching machinery conserved in all
eukaryotes from yeast to human. Arp2/3 complex branched networks generate pushing …

Mitochondrial transport along microtubules is mediated by Miro1 and TRAK adaptors that
recruit kinesin-1 and dynein-dynactin. To understand how these opposing motors are …

Abstract Knowledge of the three-dimensional structures of proteins and other biological
macromolecules often aids understanding of how they perform complicated tasks in the cell …