Defining and managing COVID-19-associated pulmonary aspergillosis: the 2020 ECMM/ISHAM consensus criteria for research and clinical guidance
Severe acute respiratory syndrome coronavirus 2 causes direct damage to the airway
epithelium, enabling aspergillus invasion. Reports of COVID-19-associated pulmonary …
epithelium, enabling aspergillus invasion. Reports of COVID-19-associated pulmonary …
The antifungal pipeline: fosmanogepix, ibrexafungerp, olorofim, opelconazole, and rezafungin
The epidemiology of invasive fungal infections is changing, with new populations at risk and
the emergence of resistance caused by the selective pressure from increased usage of …
the emergence of resistance caused by the selective pressure from increased usage of …
A marine microbiome antifungal targets urgent-threat drug-resistant fungi
New antifungal drugs are urgently needed to address the emergence and transcontinental
spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging …
spread of fungal infectious diseases, such as pandrug-resistant Candida auris. Leveraging …
Fosmanogepix: a review of the first-in-class broad spectrum agent for the treatment of invasive fungal infections
KJ Shaw, AS Ibrahim - Journal of Fungi, 2020 - mdpi.com
Fosmanogepix is a first-in-class antifungal currently in Phase 2 clinical trials for the treatment
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …
of invasive fungal infections caused by Candida, Aspergillus and rare molds. Fosmanogepix …
[PDF][PDF] Hope on the horizon: novel fungal treatments in development
The treatment of invasive fungal infections remains challenging due to limitations in currently
available antifungal therapies including toxicity, interactions, restricted routes of …
available antifungal therapies including toxicity, interactions, restricted routes of …
Pharmacodynamics, mechanisms of action and resistance, and spectrum of activity of new antifungal agents
NP Wiederhold - Journal of Fungi, 2022 - mdpi.com
Several new antifungals are currently in late-stage development, including those with novel
pharmacodynamics/mechanisms of action that represent new antifungal classes …
pharmacodynamics/mechanisms of action that represent new antifungal classes …
A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise
The emergence of new fungal pathogens makes the development of new antifungal drugs a
medical imperative that in recent years motivates the talents of numerous investigators …
medical imperative that in recent years motivates the talents of numerous investigators …
Treatment of Cryptococcal meningitis: how have we got here and where are we going?
NTT Ngan, B Flower, JN Day - Drugs, 2022 - Springer
Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but …
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Fungal infections are on the rise, driven by a growing population at risk and climate change.
Currently available antifungals include only five classes, and their utility and efficacy in …
Currently available antifungals include only five classes, and their utility and efficacy in …
Aspergillus fumigatus and aspergillosis: From basics to clinics
The airborne fungus Aspergillus fumigatus poses a serious health threat to humans by
causing numerous invasive infections and a notable mortality in humans, especially in …
causing numerous invasive infections and a notable mortality in humans, especially in …