Non-coding RNAs in disease: from mechanisms to therapeutics

K Nemeth, R Bayraktar, M Ferracin… - Nature Reviews Genetics, 2024 - nature.com
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are
not translated into proteins. Since their discovery, ncRNAs have emerged as important …

The conne**on between sex and immune responses

KS Forsyth, N Jiwrajka, CD Lovell… - Nature Reviews …, 2024 - nature.com
There are notable sex-based differences in immune responses to pathogens and self-
antigens, with female individuals exhibiting increased susceptibility to various autoimmune …

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY **ang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
Exosomes play a role as mediators of cell-to-cell communication, thus exhibiting pleiotropic
activities to homeostasis regulation. Exosomal non-coding RNAs (ncRNAs), mainly …

Gene regulation in time and space during X-chromosome inactivation

A Loda, S Collombet, E Heard - Nature Reviews Molecular Cell Biology, 2022 - nature.com
X-chromosome inactivation (XCI) is the epigenetic mechanism that ensures X-linked dosage
compensation between cells of females (XX karyotype) and males (XY). XCI is essential for …

The role of non-coding RNAs in oncology

FJ Slack, AM Chinnaiyan - Cell, 2019 - cell.com
For decades, research into cancer biology focused on the involvement of protein-coding
genes. Only recently was it discovered that an entire class of molecules, termed non-coding …

Small and long non-coding RNAs: Past, present, and future

LL Chen, VN Kim - Cell, 2024 - cell.com
Since the introduction of the central dogma of molecular biology in 1958, various RNA
species have been discovered. Messenger RNAs transmit genetic instructions from DNA to …

Functional classification and experimental dissection of long noncoding RNAs

F Kopp, JT Mendell - Cell, 2018 - cell.com
Over the last decade, it has been increasingly demonstrated that the genomes of many
species are pervasively transcribed, resulting in the production of numerous long noncoding …

Noncoding RNA: RNA regulatory networks in cancer

JJ Chan, Y Tay - International journal of molecular sciences, 2018 - mdpi.com
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This
largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and …

Nanopore native RNA sequencing of a human poly (A) transcriptome

RE Workman, AD Tang, PS Tang, M Jain, JR Tyson… - Nature …, 2019 - nature.com
High-throughput complementary DNA sequencing technologies have advanced our
understanding of transcriptome complexity and regulation. However, these methods lose …

The changing face of Turner syndrome

CH Gravholt, M Viuff, J Just, K Sandahl… - Endocrine …, 2023 - academic.oup.com
Turner syndrome (TS) is a condition in females missing the second sex chromosome (45, X)
or parts thereof. It is considered a rare genetic condition and is associated with a wide range …