Photons or electrons? A critical comparison of electrochemistry and photoredox catalysis for organic synthesis
Redox processes are at the heart of synthetic methods that rely on either electrochemistry or
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …
photoredox catalysis, but how do electrochemistry and photoredox catalysis compare? Both …
What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives
K Peng, BB Liang, W Liu, ZW Mao - Coordination Chemistry Reviews, 2021 - Elsevier
Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …
intensive works have been conducted to explore more platinum coordination complexes as …
Photocatalytic umpolung strategy for the synthesis of α-amino phosphine oxides and deuterated derivatives
C Ma, X Li, X Chen, X He, ST Zhang, YQ Jiang… - Organic …, 2023 - ACS Publications
Direct, economical, and green synthesis of deuterated α-amino phosphine oxides remains
an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven …
an elusive challenge in synthetic chemistry. Herein, we report a visible-light-driven …
Regio-and stereoselective access to highly substituted vinylphosphine oxides via metal-free electrophilic phosphonoiodination of alkynes
B Dong, F Zhao, WX Lv, YG Liu, D Wei, J Wu… - Nature …, 2024 - nature.com
In general, the P-centered ring-opening of quaternary phosphirenium salts (QPrS)
predominantly leads to hydrophosphorylated products, while the C-centered ring-opening is …
predominantly leads to hydrophosphorylated products, while the C-centered ring-opening is …
Recent Advances in the Construction of Phosphorus‐Substituted Heterocycles, 2009–2019
L Chen, XY Liu, YX Zou - Advanced Synthesis & Catalysis, 2020 - Wiley Online Library
Phosphorus‐substituted heterocycles represent an important class of organophosphorus
compounds, which not only widely exist in biologically active pharmaceuticals …
compounds, which not only widely exist in biologically active pharmaceuticals …
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use
Abstract The bisphosphonates ((HO) 2 P (O) CR 1 R 2 P (O)(OH) 2, BPs) were first shown to
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
inhibit bone resorption in the 1960s, but it was not until 30 years later that a detailed …
Phosphine Oxides from a Medicinal Chemist's Perspective: Physicochemical and in Vitro Parameters Relevant for Drug Discovery
P Finkbeiner, JP Hehn, C Gnamm - Journal of Medicinal …, 2020 - ACS Publications
Phosphine oxides and related phosphorus-containing functional groups such as
phosphonates and phosphinates are established structural motifs that are still …
phosphonates and phosphinates are established structural motifs that are still …
Selected organophosphorus compounds with biological activity. Applications in medicine
S Demkowicz, J Rachon, M Daśko, W Kozak - RSC advances, 2016 - pubs.rsc.org
The purpose of this article is to provide an overview of the latest applications of
organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs …
organophosphorus compounds (OPs) that exhibit biological activity. A large family of OPs …
The role of the phosphorus atom in drug design
Although the phosphorus atom is found in a variety of oxidation states, most of the
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
phosphorus‐containing molecules of pharmacological importance possess phosphorus in …
Enantioselective Palladium‐Catalyzed Hydrophosphinylation of Allenes with Phosphine Oxides: Access to Chiral Allylic Phosphine Oxides
Z Yang, J Wang - Angewandte Chemie, 2021 - Wiley Online Library
A Pd‐catalyzed hydrophosphinylation of alkyl and aryl‐oxyallenes with phosphine oxides
has been developed for the efficient and rapid construction of a family of chiral allylic …
has been developed for the efficient and rapid construction of a family of chiral allylic …