Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …

Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Most photocrosslinkable hydrogels have inadequacy in either mechanical performance or
biodegradability. This issue is addressed by adopting a novel hydrogel design by …

Drug combinations are widely used in clinical practice to prevent the evolution of resistance.
However, little is known about the effect of tolerance, a different mode of survival, on the …

The spread of antibiotic resistance is attracting increased attention to combination-based
treatments. Although drug combinations have been studied extensively for their effects on …

Antibiotic tolerance is associated with the failure of antibiotic treatment and the relapse of
many bacterial infections. However, unlike resistance, which is commonly measured using …

Effective crop protection is vital to safeguard food security, but growers are reliant on a
limited toolbox in the face of diverse and evolving pathogens. New crop protection methods …

BACKGROUND Antibiotics are among the most important tools in medicine, but their efficacy
is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance …

Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

A declining pipeline of clinically useful antibiotics has made it imperative to develop more
effective antimicrobial therapies, particularly against difficult-to-treat Gram-negative …