The role of histone modifications: from neurodevelopment to neurodiseases
J Park, K Lee, K Kim, SJ Yi - Signal transduction and targeted therapy, 2022 - nature.com
Epigenetic regulatory mechanisms, including DNA methylation, histone modification,
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
chromatin remodeling, and microRNA expression, play critical roles in cell differentiation …
Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders
Post-translational modification (PTM) in histone proteins is a covalent modification which
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
mainly consists of methylation, phosphorylation, acetylation, ubiquitylation, SUMOylation …
Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways
Genome-wide association studies (GWAS) of psychiatric disorders have identified multiple
genetic associations with such disorders, but better methods are needed to derive the …
genetic associations with such disorders, but better methods are needed to derive the …
Epigenetic basis of mental illness
Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …
neural circuit structure and function as well as likely abnormalities in glial cells. While …
Cannabis and the develo** brain: insights into its long-lasting effects
The recent shift in sociopolitical debates and growing liberalization of cannabis use across
the globe has raised concern regarding its impact on vulnerable populations, such as …
the globe has raised concern regarding its impact on vulnerable populations, such as …
Epigenetic mechanisms in schizophrenia and other psychotic disorders: a systematic review of empirical human findings
Schizophrenia and other psychotic disorders are highly debilitating psychiatric conditions
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
that lack a clear etiology and exhibit polygenic inheritance underlain by pleiotropic genes …
Histone methylation regulates memory formation
S Gupta, SY Kim, S Artis, DL Molfese… - Journal of …, 2010 - Soc Neuroscience
It has been established that regulation of chromatin structure through post-translational
modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an …
modification of histone proteins, primarily histone H3 phosphorylation and acetylation, is an …
Epigenetic modifications in schizophrenia and related disorders: molecular scars of environmental exposures and source of phenotypic variability
J Richetto, U Meyer - Biological Psychiatry, 2021 - Elsevier
Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
pathophysiology of schizophrenia and other psychiatric disorders with developmental …
Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …
that causes very significant disability in young people. While schizophrenia has a strong …
GABA neurons and the mechanisms of network oscillations: implications for understanding cortical dysfunction in schizophrenia
Synchronization of neuronal activity in the neocortex may underlie the coordination of neural
representations and thus is critical for optimal cognitive function. Because cognitive deficits …
representations and thus is critical for optimal cognitive function. Because cognitive deficits …