Nonprogressive congenital ataxias

E Bertini, G Zanni, E Boltshauser - Handbook of clinical neurology, 2018 - Elsevier
The terminology of nonprogressive congenital ataxia (NPCA) refers to a clinically and
genetically heterogeneous group of disorders characterized by congenital or early-onset …

Epithelioid hemangioendothelioma as a model of YAP/TAZ-driven cancer: insights from a rare fusion sarcoma

JM Lamar, V Motilal Nehru, G Weinberg - Cancers, 2018 - mdpi.com
Epithelioid hemangioendothelioma (EHE) is a rare soft-tissue sarcoma involving cells with
histologic markers that suggest an endothelial origin. Around 90% of EHEs are caused by …

De novo DNA methylation controls neuronal maturation during adult hippocampal neurogenesis

S Zocher, RW Overall, G Berdugo‐Vega, N Rund… - The EMBO …, 2021 - embopress.org
Adult neurogenesis enables the life‐long addition of functional neurons to the hippocampus
and is regulated by both cell‐intrinsic molecular programs and behavioral activity. De novo …

Networks of cultured iPSC-derived neurons reveal the human synaptic activity-regulated adaptive gene program

P Pruunsild, CP Bengtson, H Bading - Cell reports, 2017 - cell.com
Long-term adaptive responses in the brain, such as learning and memory, require synaptic
activity-regulated gene expression, which has been thoroughly investigated in rodents …

DNA methylation as a potential mediator of the association between prenatal tobacco and alcohol exposure and child neurodevelopment in a South African birth …

S Abrishamcar, J Chen, D Feil, A Kilanowski… - Translational …, 2022 - nature.com
Prenatal tobacco exposure (PTE) and prenatal alcohol exposure (PAE) have been
associated with an increased risk of delayed neurodevelopment in children as well as …

Developmental cannabidiol exposure increases anxiety and modifies genome-wide brain DNA methylation in adult female mice

NM Wanner, M Colwell, C Drown, C Faulk - Clinical epigenetics, 2021 - Springer
Background Use of cannabidiol (CBD), the primary non-psychoactive compound found in
cannabis, has recently risen dramatically, while relatively little is known about the underlying …

Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages

Z Zhang, R Butler, DC Koestler, S Bell-Glenn… - Clinical …, 2022 - Springer
Background There is considerable evidence that epigenetic mechanisms and DNA
methylation are critical drivers of immune cell lineage differentiation and activation …

Lineage divergence of activity-driven transcription and evolution of cognitive ability

GE Hardingham, P Pruunsild, ME Greenberg… - Nature Reviews …, 2018 - nature.com
Excitation–transcription coupling shapes network formation during brain development and
controls neuronal survival, synaptic function and cognitive skills in the adult. New studies …

Unraveling the biology of epithelioid hemangioendothelioma, a TAZ–CAMTA1 fusion driven sarcoma

CN Seavey, AV Pobbati, BP Rubin - Cancers, 2022 - mdpi.com
Simple Summary Epithelioid hemangioendothelioma (EHE) is a rare vascular cancer that
involves a gain-of-function gene fusion involving TAZ, a transcriptional coactivator, and one …

Robust and annotation-free analysis of alternative splicing across diverse cell types in mice

G Benegas, J Fischer, YS Song - Elife, 2022 - elifesciences.org
Although alternative splicing is a fundamental and pervasive aspect of gene expression in
higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges …