The study of Drosophila imaginal discs has contributed to a number of discoveries in
developmental and cellular biology. In addition to the elucidation of the role of tissue …

The study of regeneration in Drosophila imaginal discs provides an opportunity to use
powerful genetic tools to address fundamental problems pertaining to tissue regeneration …

The Drosophila wing imaginal disc is a tissue of undifferentiated cells that are precursors of
the wing and most of the notum of the adult fly. The wing disc first forms during …

Many organisms lose the capacity to regenerate damaged tissues as they mature. Damaged
Drosophila imaginal discs regenerate efficiently early in the third larval instar (L3) but …

Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner
involving local cell proliferation at the wound site. After disc fragmentation, cells at the …

Understanding the molecular basis of wound healing and regeneration in vertebrates is one
of the main challenges in biology and medicine. This understanding will lead to medical …

Homeostatic renewal and stress-related tissue regeneration rely on stem cell activity, which
drives the replacement of damaged cells to maintain tissue integrity and function. The Jun N …

Regenerating tissue must initiate the signaling that drives regenerative growth, and sustain
that signaling long enough for regeneration to complete. How these key signals are …

Apoptosis is an ancient and evolutionarily conserved cell suicide program. During
apoptosis, executioner caspase enzyme activation has been considered a point of no return …

The mystery of appendage regeneration has fascinated humans for centuries, while the
underlying regulatory mechanisms remain unclear. In this study, we establish a …