Small GTP-binding proteins (G proteins) exist in eukaryotes from yeast to human and
constitute a superfamily consisting of more than 100 members. This superfamily is …

Many features of cell behavior are regulated by Rho family GTPases, but the most profound
effects of these proteins are on the actin cytoskeleton and it was these that first drew …

The BAR (Bin/amphiphysin/Rvs) domain is the most conserved feature in amphiphysins from
yeast to human and is also found in endophilins and nadrins. We solved the structure of the …

Rho GTPases are molecular switches that regulate many essential cellular processes,
including actin dynamics, gene transcription, cell-cycle progression and cell adhesion …

The Rho GTPases form a subgroup of the Ras superfamily of 20-to 30-kD GTP-binding
proteins that have been shown to regulate a wide spectrum of cellular functions. These …

The ADP-ribosylation factor (ARF) small GTPases regulate vesicular traffic and organelle
structure by recruiting coat proteins, regulating phospholipid metabolism and modulating the …

▪ Abstract The 3-phosphorylated inositol lipids fulfill roles as second messengers by
interacting with the lipid binding domains of a variety of cellular proteins. Such interactions …

Intracellular pathogens and the molecules they express have limited contact with the
immune system. Here, we show that macrophages infected with intracellular pathogens …

The process of engulfing a foreign particle–phagocytosis–is of fundamental importance for a
wide diversity of organisms. From simple unicellular organisms that use phagocytosis to …

To facilitate a rapid response to environmental change, cells use scaffolding—or adaptor—
proteins to recruit key components of their signal-transduction machinery to specific …