Effective diagnosis, prognostication, and management of CNS malignancies traditionally
involves invasive brain biopsies that pose significant risk to the patient. Sampling and …

Background The utility of liquid biopsies is well documented in several extracranial and
intracranial (brain/leptomeningeal metastases, gliomas) tumors. Methods The RANO …

Background Molecular brain tumor diagnosis is usually dependent on tissue biopsies or
resections. This can pose several risks associated with anesthesia or neurosurgery …

Brain tumors represent some of the most aggressive malignancies. The latest WHO
Classification of Tumors of the Central Nervous System recognizes more than 100 primary …

Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …

Pediatric central nervous system tumors remain challenging to diagnose. Imaging
approaches do not provide sufficient detail to discriminate between different tumor types …

Purpose: Primary central nervous system (CNS) gliomas can be classified by characteristic
genetic alterations. In addition to solid tissue obtained via surgery or biopsy, cell-free DNA …

Simple Summary We demonstrate that, in pediatric embryonal brain tumors, cell-free DNA
extracted from CSF can be used for whole exome sequencing (WES), with informative …

Glioblastoma (GBM), the most common and aggressive primary central nervous system
(CNS) tumor in adults, continues to have a dismal prognosis. Across hundreds of clinical …

Early detection is warranted to improve prognosis of gastric cancer (GC) but remains
challenging. Liquid biopsy combined with machine learning will provide new insights into …