Although commercial entities can contribute positively to health and society there is growing
evidence that the products and practices of some commercial actors—notably the largest …

Adverse drug reactions (ADRs) and drug-induced toxicity are major challenges in drug
discovery, threatening patient safety and dramatically increasing healthcare expenditures …

Introduction In 2020, prior to COVID-19 vaccine rollout, the Brighton Collaboration created a
priority list, endorsed by the World Health Organization, of potential adverse events relevant …

The suite of currently used drugs can be divided into two categories–traditional 'small
molecule'drugs with typical molecular weights of< 500 Da but with oral bioavailability, and …

Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical,
emotional and socioeconomic consequences. Despite advances in targeted biologic and …

PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART
DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the …

Amphiphilic self‐immolative polymers (SIPs) can achieve complete degradation solely
through one triggerable event, which potentially optimize the blood clearance and …

Context Previous studies indicate that the interpretation of trial results can be distorted by
authors of published reports. Objective To identify the nature and frequency of distorted …

Clinical trial data have prompted questions about the degree to which patients and their
physicians should consider an increased risk of cardiovascular or cerebrovascular events …

Reporting bias represents a major problem in the assessment of health care interventions.
Several prominent cases have been described in the literature, for example, in the reporting …