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The how and why of lncRNA function: an innate immune perspective
Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …
Technological developments in lncRNA biology
It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …
[HTML][HTML] Small RNAs are modified with N-glycans and displayed on the surface of living cells
Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …
Atlas of subcellular RNA localization revealed by APEX-Seq
We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …
RNA structure maps across mammalian cellular compartments
RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …
Long non-coding RNA structure and function: is there a link?
RNA has emerged as the prime target for diagnostics, therapeutics and the development of
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …
Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures
Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …
regulation, and dynamically reflect specific cellular conditions. However, presently available …
Platforms for investigating LncRNA functions
Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …
for proteins. However, with the advent of next-generation sequencing, it has now been …
Cryo-EM structure of human dicer and its complexes with a pre-miRNA substrate
Human Dicer (hDicer) is a multi-domain protein belonging to the RNase III family. It plays
pivotal roles in small RNA biogenesis during the RNA interference (RNAi) pathway by …
pivotal roles in small RNA biogenesis during the RNA interference (RNAi) pathway by …
Dynamic characterization and interpretation for protein-RNA interactions across diverse cellular conditions using HDRNet
RNA-binding proteins play crucial roles in the regulation of gene expression, and
understanding the interactions between RNAs and RBPs in distinct cellular conditions forms …
understanding the interactions between RNAs and RBPs in distinct cellular conditions forms …