The term autophagy encompasses different pathways that route cytoplasmic material to
lysosomes for degradation and includes macroautophagy, chaperone-mediated autophagy …

Exciting new discoveries have transformed the view of the lysosome from a static organelle
dedicated to the disposal and recycling of cellular waste to a highly dynamic structure that …

Cells respond to mitochondrial poisons with rapid activation of the adenosine
monophosphate–activated protein kinase (AMPK), causing acute metabolic changes …

Protein kinase RNA‐like ER kinase (PERK) is an endoplasmic reticulum (ER) stress sensor
that responds to the accumulation of misfolded proteins. Once activated, PERK initiates …

An emerging role for the circadian clock in autophagy and lysosome function has opened
new avenues for exploration in the field of neurodegeneration. The daily rhythms of …

Circadian rhythms govern a large array of physiological and metabolic functions.
Perturbations of the daily cycle have been linked to elevated risk of develo** cancer as …

Metabolic demands fluctuate rhythmically and rely on coordination between the circadian
clock and nutrient-sensing signalling pathways, yet mechanisms of their interaction remain …

Circadian rhythms align physiological functions with the light–dark cycle through oscillatory
changes in the abundance of proteins in the clock transcriptional programme. Timely …

The regulation of autophagy-dependent lysosome homeostasis in vivo is unclear. We
showed that the inositol polyphosphate 5-phosphatase INPP5K regulates autophagic …

The meal distribution of proteins throughout the day is usually skewed. However, its
physiological implications and the effects of better protein distribution on muscle volume are …