Sepsis: mechanisms of bacterial injury to the patient

H Minasyan - Scandinavian journal of trauma, resuscitation and …, 2019 - Springer
In bacteremia the majority of bacterial species are killed by oxidation on the surface of
erythrocytes and digested by local phagocytes in the liver and the spleen. Sepsis-causing …

Sepsis and septic shock: Pathogenesis and treatment perspectives

H Minasyan - Journal of critical care, 2017 - Elsevier
The majority of bacteremias do not develop to sepsis: bacteria are cleared from the
bloodstream. Oxygen released from erythrocytes and humoral immunity kill bacteria in the …

Pore size–a key property for selective toxin removal in blood purification

S Harm, D Falkenhagen… - The International Journal …, 2014 - journals.sagepub.com
Purpose Extracorporeal blood purification systems based on combined
membrane/adsorption technologies are used in acute liver failure to replace detoxification …

Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent

A Osmokrovic, I Jancic, J Vunduk, P Petrovic… - Carbohydrate …, 2018 - Elsevier
New composites based on Ca-alginate hydrogels were produced that release activated
charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial …

Mesoporous carbide-derived carbon for cytokine removal from blood plasma

S Yachamaneni, G Yushin, SH Yeon, Y Gogotsi… - Biomaterials, 2010 - Elsevier
Porous carbons can be used for purification of bio-fluids due to their excellent
biocompatibility with blood. Since the ability to adsorb a range of inflammatory cytokines …

A haemocompatible and scalable nanoporous adsorbent monolith synthesised using a novel lignin binder route to augment the adsorption of poorly removed uraemic …

SR Sandeman, Y Zheng, GC Ingavle… - Biomedical …, 2017 - iopscience.iop.org
Nanoporous adsorbents are promising materials to augment the efficacy of haemodialysis
for the treatment of end stage renal disease where mortality rates remain unacceptably high …

[HTML][HTML] A historical perspective on sepsis

PA Ward, M Bosmann - The American journal of pathology, 2012 - Elsevier
In North America, approximately 700,000 cases of sepsis occur each year, with mortality
ranging between 30% and 50%. The American Journal of Pathology has featured numerous …

A novel therapeutic approach to modulate the inflammatory cascade: A timely exogenous local inflammatory response attenuates the sepsis-induced cytokine storm

M Gong, S Qi, Z Wu, Y Huang, L Wu, X Wang, L He… - Cytokine, 2024 - Elsevier
Background The emergence of severe sepsis is contingent upon the occurrence of a
cytokine storm (CS), a multifaceted process intricately entwined with the temporal …

Graphene-based materials for the fast removal of cytokines from blood plasma

M Seredych, B Haines, V Sokolova… - ACS applied bio …, 2018 - ACS Publications
There is a range of medical conditions, which include acute organ failure, bacterial and viral
infection, and sepsis, that result in overactivation of the inflammatory response of the …

[PDF][PDF] Hierarchical porous carbide-derived carbons for the removal of cytokines from blood plasma

V Presser, SH Yeon, C Vakifahmetoglu… - Adv. Healthcare …, 2012 - academia.edu
Hypercytokinemia, also called “cytokine storm”, is an exaggerated immune response to
either acute or chronic injuries.[1] A positive feedback loop between cytokines and immune …