Neurodegenerative diseases represent a formidable challenge to global health. As
advances in other areas of medicine grant healthy living into later decades of life, aging …

Neurodegenerative Diseases (NDDs) are a group of disorders that cause progressive
deficits of neuronal function. Recent evidence argues that sphingolipid metabolism is …

The accumulation of reactive oxygen species (ROS) is a common feature of tauopathies,
defined by Tau accumulations in neurons and glia. High ROS in neurons causes lipid …

Daily rhythms in behavior emerge from networks of neurons that express molecular clocks.
Drosophila's clock neuron network consists of a diversity of cell types, yet is modeled as two …

To survive adverse environments, many animals enter a dormant state such as hibernation,
dauer, or diapause. Various Drosophila species undergo adult reproductive diapause in …

The Integrator complex is a multi-subunit protein complex that regulates the processing of
nascent RNAs transcribed by RNA polymerase II (RNAPII), including small nuclear RNAs …

The Drosophila mushroom body (MB) is a key associative memory center that has also been
implicated in the control of sleep. However, the identity of MB neurons underlying …

Genome-wide association studies (GWAS) in humans have identified loci robustly
associated with several heritable diseases or traits, yet little is known about the functional …

One output arm of the sleep homeostat in Drosophila appears to be a group of neurons with
projections to the dorsal fan-shaped body (dFB neurons) of the central complex in the brain …

Drosophila melanogaster has been widely used in the biological sciences as a model
organism. Drosophila has a relatively short life span of 60–80 days, which makes it attractive …