Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

The current predominant therapeutic paradigm is based on maximizing drug-receptor
occupancy to achieve clinical benefit. This strategy, however, generally requires excessive …

Abstract The 3, 3′‐pyrrolidinyl‐spirooxindole unit is a privileged heterocyclic motif that
forms the core of a large family of alkaloid natural products with strong bioactivity profiles …

Recent advances in understanding different RNAs and unique features of their biology have
revealed a wealth of information. However, approaches to identify small molecules that …

Using a diverse collection of small molecules generated from a variety of sources, we
measured protein-binding activities of each individual compound against each of 100 …

Abstract Das 3, 3′‐Pyrrolidinylspirooxindol‐System ist ein privilegiertes heterocyclisches
Strukturmotiv, das die zentrale Einheit bei einer großen Familie von natürlichen Alkaloiden …

Small-molecule inhibition of extracellular proteins that activate membrane receptors has
proven to be extremely challenging. Diversity-oriented synthesis and small-molecule …

Riboswitches are naturally occurring RNA aptamers that regulate gene expression by
binding to specific small molecules. Riboswitches control the expression of essential …

Sonic hedgehog (Shh) is the most widely characterized of the three vertebrate
Hedgehoghomologs, and is essential for proper embryonic development. Shh binds to its …