Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Orchestrating vertebrate genomes require a complex interplay between the linear
composition of the genome and its 3D organization inside the nucleus. This requires the …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Heterochromatin marks such as H3K9me3 undergo global erasure and re-establishment
after fertilization, and the proper reprogramming of H3K9me3 is essential for early …

Over the past decade, genome-wide assays for chromatin interactions in single cells have
enabled the study of individual nuclei at unprecedented resolution and throughput. Current …

Markedly expanded tandem repeats (TRs) have been correlated with~ 60 diseases. TR
diversity has been considered a clue toward understanding missing heritability. However …