Glioblastoma (GBM) is the most aggressive and deadliest of the primary brain tumors,
characterized by malignant growth, invasion into the brain parenchyma, and resistance to …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

There is a growing recognition that gliomas are complex tumors composed of neoplastic and
non-neoplastic cells, which each individually contribute to cancer formation, progression …

Exosomes, the cell-derived small extracellular vehicles, play a vital role in intracellular
communication by reciprocally transporting DNA, RNA, bioactive protein, chains of glucose …

Simple Summary Patients with glioblastoma—the most frequent and malignant primary brain
tumor—have a poor prognosis with a median survival of less than 15 months. Despite …

CNS immune defenses are marshaled and dominated by brain resident macrophages and
microglia, which are the innate immune sentinels and frontline host immune barriers against …

Spatiotemporal regulation of tumor immunity remains largely unexplored. Here we identify a
vascular niche that controls alternative macrophage activation in glioblastoma (GBM). We …

Glioma is a mixed solid tumor composed of neoplastic and non-neoplastic components.
Glioma-associated macrophages and microglia (GAMs) are crucial elements of the glioma …

High-grade gliomas are rapidly progressing tumors of the central nervous system (CNS) with
a very poor prognosis despite extensive resection combined with radiation and/or …

In recent years, the functions of glial cells, namely, astrocytes and microglia, have gained
prominence in several diseases of the central nervous system, especially in glioblastoma …