Regeneration of pancreatic beta cells by modulation of molecular targets using plant-derived compounds: pharmacological mechanisms and clinical potential
Type 2 diabetes (T2D) is characterized by pancreatic beta-cell dysfunction, increased cell
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …
death and loss of beta-cell mass despite chronic treatment. Consequently, there has been …
Ethnopharmacology and therapeutic potentials of Oxalis corniculata: an in-depth study
Background For centuries, plants have been used in the folk medicine of various cultures for
their healing properties. It is amazing how nature has provided us with such powerful …
their healing properties. It is amazing how nature has provided us with such powerful …
An in silico approach to target RNA-dependent RNA polymerase of COVID-19 with naturally occurring phytochemicals
HS Mahrosh, G Mustafa - Environment, Development and Sustainability, 2021 - Springer
The novel coronavirus disease 2019 (COVID-19) was firstly reported from Wuhan city of
China and found as a highly contagious, transmittable and pathogenic viral infection. The …
China and found as a highly contagious, transmittable and pathogenic viral infection. The …
LC‐ESI‐QTOF‐MS for the Profiling of the Metabolites and in Vitro Enzymes Inhibition Activity of Bryophyllum pinnatum and Oxalis corniculata Collected from …
The objective of this study was to profile the chemical components and biological activity
analysis of crude extract of Bryophyllum pinnatum and Oxalis corniculata. Results revealed …
analysis of crude extract of Bryophyllum pinnatum and Oxalis corniculata. Results revealed …
Gymnemic acid ameliorates pancreatic β-cell dysfunction by modulating Pdx1 expression: a possible strategy for β-cell regeneration
Background: Endogenous pancreatic β-cell regeneration is a promising therapeutic
approach for enhancing β-cell function and neogenesis in diabetes. Various findings have …
approach for enhancing β-cell function and neogenesis in diabetes. Various findings have …
Encapsulation of telmisartan inside insulinoma-cell-derived extracellular vesicles outperformed biomimetic nanovesicles in modulating the pancreatic inflammatory …
A Singh, SK Pore, J Bhattacharyya - Journal of Materials Chemistry B, 2024 - pubs.rsc.org
Diabetes mellitus (DM) is a chronic metabolic condition, characterized by hyperglycaemia,
oxidative imbalance, pancreatic β-cell death, and insulin insufficiency. Angiotensin II (Ang II) …
oxidative imbalance, pancreatic β-cell death, and insulin insufficiency. Angiotensin II (Ang II) …
MicroRNA-17-92 regulates beta-cell restoration after streptozotocin treatment
S Wan, J Zhang, X Chen, J Lang, L Li, F Chen… - Frontiers in …, 2020 - frontiersin.org
Objective: To clarify the role and mechanism of miR-17-92 cluster in islet beta-cell repair
after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92 βKO) …
after streptozotocin intervention. Methods: Genetically engineered mice (miR-17-92 βKO) …
[HTML][HTML] HPTLC quantification, assessment of antioxidant potential and in vivo hypoglycemic activity of Scorzonera latifolia (Fisch. & CA Mey.) DC. and its major …
Scorzonera L.(Asteraceae) species have long been the topic of many phytochemical,
analytical, and biological studies since various species of the Scorzonera genus have been …
analytical, and biological studies since various species of the Scorzonera genus have been …
Differences in glucose homeostasis and islet injury among diverse mice strains post acute pancreatitis
D Du, X Wang, H Zuo, L Li, H Hao, G Hou, P Gu… - Biochemical and …, 2024 - Elsevier
Diverse animal models have been used to study postpancreatitis diabetes mellitus (PPDM)
development; however, no study has yet conducted a comparative analysis of the specific …
development; however, no study has yet conducted a comparative analysis of the specific …
Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy
Failing pancreas and subsequent loss of pancreatic β cells worsen diabetic conditions
which are further alleviated by the mounting up of glucose levels. Inhibition of sodium …
which are further alleviated by the mounting up of glucose levels. Inhibition of sodium …