The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an
imminent global public health problem. Local application of antibiotics might be a solution. In …

Orthopaedic implants are recognised as important therapeutic devices in the successful
clinical management of a wide range of orthopaedic conditions. However, implant-related …

Systematically identifying functional peptides is difficult owing to the vast combinatorial
space of peptide sequences. Here we report a machine-learning pipeline that mines the …

Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential
solution to the multi-drug resistance problem. In particular, short-length AMPs have been …

Revascularization plays a critical role in the healing of diabetic wounds. Accumulation of
advanced glycation end products (AGEs) and refractory multidrug resistant bacterial …

Infectious diseases are one of the main causes of human morbidity and mortality. In the last
few decades, pathogenic microorganisms' resistance to conventional drugs has been …

Despite advanced implant sterilization and aseptic surgical techniques, periprosthetic
bacterial infection remains a major challenge for orthopedic and dental implants. Bacterial …

Abstract KR-12-a5 is a 12-meric α-helical antimicrobial peptide (AMP) with dual
antimicrobial and anti-inflammatory activities designed from human cathelicidin LL-37. We …

Antimicrobial peptides (AMPs), as evolutionarily conserved components of innate immune
system, protect against pathogens including bacteria, fungi, viruses, and parasites. In …

To combat infection by microorganisms host organisms possess a primary arsenal via the
innate immune system. Among them are defense peptides with the ability to target a wide …