Strategies to address low drug solubility in discovery and development
Drugs with low water solubility are predisposed to low and variable oral bioavailability and,
therefore, to variability in clinical response. Despite significant efforts to “design in” …
therefore, to variability in clinical response. Despite significant efforts to “design in” …
Delivery of lipophilic bioactives: assembly, disassembly, and reassembly of lipid nanoparticles
The oral bioavailability of lipophilic bioactive molecules can be greatly increased by
encapsulating them within engineered lipid nanoparticles (ELNs), such as micelles …
encapsulating them within engineered lipid nanoparticles (ELNs), such as micelles …
Investigation of pH and temperature profiles in the GI tract of fasted human subjects using the Intellicap® system
M Koziolek, M Grimm, D Becker, V Iordanov… - Journal of …, 2015 - Elsevier
Gastrointestinal (GI) pH and temperature profiles under fasted-state conditions were
investigated in two studies with each 10 healthy human subjects using the IntelliCap® …
investigated in two studies with each 10 healthy human subjects using the IntelliCap® …
Prolonged energy harvesting for ingestible devices
Ingestible electronics have revolutionized the standard of care for a variety of health
conditions. Extending the capacity and safety of these devices, and reducing the costs of …
conditions. Extending the capacity and safety of these devices, and reducing the costs of …
pH‐Responsive β‐Glucans‐Complexed mRNA in LNPs as an Oral Vaccine for Enhancing Cancer Immunotherapy
PK Luo, HM Ho, MC Chiang, LA Chu… - Advanced …, 2024 - Wiley Online Library
Abstract mRNA vaccines for cancer immunotherapy are commonly delivered using lipid
nanoparticles (LNPs), which, when administered intravenously, may accumulate in the liver …
nanoparticles (LNPs), which, when administered intravenously, may accumulate in the liver …
Toward the establishment of standardized in vitro tests for lipid-based formulations, part 1: method parameterization and comparison of in vitro digestion profiles …
The Lipid Formulation Classification System Consortium is an industry–academia
collaboration, established to develop standardized in vitro methods for the assessment of …
collaboration, established to develop standardized in vitro methods for the assessment of …
Food for thought: formulating away the food effect–a PEARRL review
Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have …
[HTML][HTML] A method based on 1H NMR spectral data useful to evaluate the hydrolysis level in complex lipid mixtures
B Nieva-Echevarría, E Goicoechea… - Food Research …, 2014 - Elsevier
A new approach is reported, based on Proton Nuclear Magnetic Resonance (1 H NMR)
spectral data, to study qualitatively and quantitatively the hydrolysis level in complex lipid …
spectral data, to study qualitatively and quantitatively the hydrolysis level in complex lipid …
Transglutaminase 3 crosslinks the secreted gel-forming mucus component Mucin-2 and stabilizes the colonic mucus layer
JDA Sharpen, B Dolan, EEL Nyström… - Nature …, 2022 - nature.com
The colonic mucus layer is organized as a two-layered system providing a physical barrier
against pathogens and simultaneously harboring the commensal flora. The factors …
against pathogens and simultaneously harboring the commensal flora. The factors …
Dietary fat and gut microbiota: mechanisms involved in obesity control
OGL Coelho, FG Cândido… - Critical reviews in food …, 2019 - Taylor & Francis
Obesity is a serious global health problem that is directly related to various morbidities
manifestation. Intestinal dysbiosis has been implicated on obesity pathogenesis. Diet …
manifestation. Intestinal dysbiosis has been implicated on obesity pathogenesis. Diet …