New developments of the principle of vinylogy as applied to π-extended enolate-type donor systems
The principle of vinylogy states that the electronic effects of a functional group in a molecule
are possibly transmitted to a distal position through interposed conjugated multiple bonds …
are possibly transmitted to a distal position through interposed conjugated multiple bonds …
Revealing the similarities of α, β‐unsaturated iminiums and acylazoliums in organocatalysis
The secondary amine‐catalyzed reactions proceeding via α, β‐unsaturated iminiums and
the N‐heterocyclic carbene (NHC)‐catalyzed transformations taking place via α, β …
the N‐heterocyclic carbene (NHC)‐catalyzed transformations taking place via α, β …
Pyrazolone: a powerful synthon for asymmetric diverse derivatizations
S Liu, X Bao, B Wang - Chemical Communications, 2018 - pubs.rsc.org
As a powerful synthon, pyrazolone has widely been exploited for the construction of various
chiral pyrazoles/pyrazolones which hold great potential in the development of …
chiral pyrazoles/pyrazolones which hold great potential in the development of …
Enantioselective Formal C(sp3)−H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives
H Li, R Gontla, J Flegel, C Merten… - Angewandte Chemie …, 2019 - Wiley Online Library
Herein, we report the first enantioselective annulation of α‐arylidene pyrazolones through a
formal C (sp3)− H activation under mild conditions enabled by highly variable RhIII‐Cpx …
formal C (sp3)− H activation under mild conditions enabled by highly variable RhIII‐Cpx …
Catalytic asymmetric synthesis of spiropyrazolones and their application in medicinal chemistry
X **e, L **ang, C Peng, B Han - The Chemical Record, 2019 - Wiley Online Library
Chiral spiropyrazolones are unique frameworks widely found in a large family of medicinally
relevant compounds with various biological activities. Substantial research efforts have been …
relevant compounds with various biological activities. Substantial research efforts have been …
Enantioselective organocatalytic michael addition reactions catalyzed by proline/prolinol/supported proline based organocatalysts: an overview
Ever since the discovery of enantioselective organocatalytic Michael addition reactions, it
has emerged as a significant path for synthesizing a variety of stereochemical products …
has emerged as a significant path for synthesizing a variety of stereochemical products …
The catalytic asymmetric synthesis of CF 3-containing spiro-oxindole–pyrrolidine–pyrazolone compounds through squaramide-catalyzed 1, 3-dipolar cycloaddition
C Wang, D Wen, H Chen, Y Deng, X Liu… - Organic & …, 2019 - pubs.rsc.org
Pharmaceutically important compounds were synthesized through the organocatalytic 1, 3-
dipolar cycloaddition reaction. In the presence of a cinchonine-derived squaramide catalyst …
dipolar cycloaddition reaction. In the presence of a cinchonine-derived squaramide catalyst …
Organocatalytic asymmetric [4+ 1] annulation of in situ generated ortho-quinomethanes with 4-halo pyrazolones: straightforward access to chiral spiro-benzofuran …
MM Chu, SS Qi, YF Wang, B Wang, ZH Jiang… - Organic Chemistry …, 2019 - pubs.rsc.org
A highly straightforward route to enantiomerically enriched spiro-benzofuran pyrazolones
has been achieved via chiral amine squaramide catalyzed [4+ 1] annulation of in situ …
has been achieved via chiral amine squaramide catalyzed [4+ 1] annulation of in situ …
One-pot asymmetric synthesis of spiropyrazolone-linked cyclopropanes and benzofurans through a general michael addition/chlorination/nucleophilic substitution …
H Lu, HX Zhang, CY Tan, JY Liu, H Wei… - The Journal of Organic …, 2019 - ACS Publications
A sequential and general strategy has been successfully developed for the synthesis of
spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent …
spiropyrazolone scaffolds. This intriguing transformation of the asymmetric multicomponent …
Catalyst-and substituent-controlled switching of chemoselectivity for the enantioselective synthesis of fully substituted cyclobutane derivatives via 2+ 2 annulation of …
PS Akula, BC Hong, GH Lee - Organic letters, 2018 - ACS Publications
The first regioselective, diastereoselective, and enantioselective organocatalyzed Michael–
Michael cascade of vinylogous ketone enolates and nitroalkenes for the construction of fully …
Michael cascade of vinylogous ketone enolates and nitroalkenes for the construction of fully …