Neural stem cell differentiation into mature neurons: mechanisms of regulation and biotechnological applications

MS Vieira, AK Santos, R Vasconcellos… - Biotechnology …, 2018 - Elsevier
The abilities of stem cells to self-renew and form different mature cells expand the
possibilities of applications in cell-based therapies such as tissue recomposition in …

[HTML][HTML] Genetic therapy for intervertebral disc degeneration

EJ Roh, A Darai, JW Kyung, H Choi, SY Kwon… - International journal of …, 2021 - mdpi.com
Intervertebral disc (IVD) degeneration can cause chronic lower back pain (LBP), leading to
disability. Despite significant advances in the treatment of discogenic LBP, the limitations of …

Pathophysiological bases of comorbidity: traumatic brain injury and post-traumatic stress disorder

GB Kaplan, KA Leite-Morris, L Wang… - Journal of …, 2018 - liebertpub.com
The high rates of traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD)
diagnoses encountered in recent years by the United States Veterans Affairs Healthcare …

[HTML][HTML] Transplantation of human neural stem cells restores cognition in an immunodeficient rodent model of traumatic brain injury

DL Haus, L López-Velázquez, EM Gold… - Experimental …, 2016 - Elsevier
Traumatic brain injury (TBI) in humans can result in permanent tissue damage and has been
linked to cognitive impairment that lasts years beyond the initial insult. Clinically effective …

How stem cells speak with host immune cells in inflammatory brain diseases

S Pluchino, C Cossetti - Glia, 2013 - Wiley Online Library
Advances in stem cell biology have raised great expectations that diseases and injuries of
the central nervous system (CNS) may be ameliorated by the development of non …

Defining recovery neurobiology of injured spinal cord by synthetic matrix-assisted hMSC implantation

AE Ropper, DK Thakor, IB Han, D Yu, X Zeng… - Proceedings of the …, 2017 - pnas.org
Mesenchymal stromal stem cells (MSCs) isolated from adult tissues offer tangible potential
for regenerative medicine, given their feasibility for autologous transplantation. MSC …

Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis

YD Teng, SC Benn, SN Kalkanis, JM Shefner… - Science translational …, 2012 - science.org
Amyotrophic lateral sclerosis (ALS) is a lethal disease characterized by the unremitting
degeneration of motor neurons. Multiple processes involving motor neurons and other cell …

[HTML][HTML] Molecular and functional verification of wharton's jelly mesenchymal stem cells (WJ-MSCs) pluripotency

A Musiał-Wysocka, M Kot, M Sułkowski… - International journal of …, 2019 - mdpi.com
The properties of mesenchymal stem cells (MSCs), especially their self-renewal and ability
to differentiate into different cell lines, are widely discussed. Considering the fact that MSCs …

[HTML][HTML] The role of the stress system in recovery after traumatic brain injury: a tribute to Bruce S. McEwen

ZM Weil, B White, B Whitehead, K Karelina - Neurobiology of Stress, 2022 - Elsevier
Traumatic brain injury (TBI) represents a major public health concern. Although the majority
of individuals that suffer mild-moderate TBI recover relatively quickly, a substantial subset of …

Neuro-immune interactions of neural stem cell transplants: from animal disease models to human trials

E Giusto, M Donegà, C Cossetti, S Pluchino - Experimental Neurology, 2014 - Elsevier
Stem cell technology is a promising branch of regenerative medicine that is aimed at
develo** new approaches for the treatment of severely debilitating human diseases …