The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for
malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a …

Lung inflammatory disorders are a major global health burden, impacting millions of people
and raising rates of morbidity and death across many demographic groups. An industrial …

Background Clinical characteristics of the international population with severe asthma are
unknown. Intercountry comparisons are hindered by variable data collection within regional …

Redox regulation participates in the control of various aspects of metabolism. Reactive
oxygen and nitrogen species participate in many reactions under physiological conditions …

BACKGROUND: Diabetes mellitus is a systemic disorder associated with inflammation and
oxidative stress which may target many organs such as the kidney, retina, and the vascular …

Allergic diseases like asthma, allergic rhinitis and dermatitis pose a significant global health
burden, driving the search for novel therapies. The NLRP3 inflammasome, a key component …

Asthma is a chronic inflammatory disorder of the airways. Schisandrin B (SB) is the main
effective component. This study investigated the effects of SB on airway inflammation and …

Background Severe asthma is complex; comorbidities may influence disease outcomes.
Objective To assess mepolizumab effectiveness in patients with severe asthma and …

Chronic and acute respiratory diseases pose a major problem for public health worldwide
due to the high morbidity and mortality rates, while treatment options remain mostly …

Background TGF-β1 can induce epithelial-mesenchymal transition (EMT) in primary airway
epithelial cells (AECs). Semaphorin7A (Sema7a) plays a crucial role in regulating immune …