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Dissecting the relationship between neuropsychiatric and neurodegenerative disorders
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …
common causes of death in elderly people, which includes progressive neuronal cell death …
Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration
R Kunze, S Fischer, HH Marti, KT Preissner - Journal of biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …
Vortioxetine ameliorates experimental autoimmune encephalomyelitis model of multiple sclerosis in mice via activation of PI3K/Akt/CREB/BDNF cascade and …
MS Shafiek, RY Mekky, NN Nassar… - European Journal of …, 2024 - Elsevier
Multiple sclerosis (MS) is a chronic condition characterized by immune cell infiltration and
cytokine overproduction that led to myelin sheath inflammatory assaults, thus causing …
cytokine overproduction that led to myelin sheath inflammatory assaults, thus causing …
TLR2 deficiency is beneficial at the late phase in MPTP-induced Parkinson'disease mice
Y He, J Zhao, H Dong, X Zhang, Y Duan, Y Ma, M Yu… - Life Sciences, 2023 - Elsevier
Aims Parkinson's disease (PD) is a progressive neurodegenerative disorder. The etiology of
PD is still elusive but neuroinflammation is proved to be an important contributor. Toll-like …
PD is still elusive but neuroinflammation is proved to be an important contributor. Toll-like …
Time-and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome
Background Inflammasome overactivation, multiprotein complexes that trigger inflammatory
responses, plays a critical role in Major Depressive Disorder (MDD) pathogenesis and …
responses, plays a critical role in Major Depressive Disorder (MDD) pathogenesis and …
[HTML][HTML] Vortioxetine improves depressive symptoms and cognition in Parkinson's disease patients with major depression: an open-label prospective study
D Santos García, MG Alonso Losada… - Brain Sciences, 2022 - mdpi.com
Depression is frequent in Parkinson's disease (PD) patients, but the evidence for many
antidepressant agents to treat it in PD is insufficient. The aim of the present prospective open …
antidepressant agents to treat it in PD is insufficient. The aim of the present prospective open …
Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor-and non-motor features of Parkinson disease in mice: Insight into mechanisms of …
Ethnopharmacological relevance Cajanus cajan (L) Millsp (Fabaceae) seed decoction is
used by traditional healers in Nigeria as nerve tonic, hence, could be beneficial in the …
used by traditional healers in Nigeria as nerve tonic, hence, could be beneficial in the …
Vortioxetine improved negative and cognitive symptoms of schizophrenia in subchronic MK-801 model in rats
Schizophrenia is a devastating psychiatric disorder with complex symptoms and
neurobiology. Serotonergic dysregulation is known to contribute to the pathogenesis of …
neurobiology. Serotonergic dysregulation is known to contribute to the pathogenesis of …
MicroRNA-gene regulatory network of TLR signaling in neuroinflammation-induced Parkinson's disease: a bioinformatics approach
Parkinson's disease (PD) is the second-most common neurodegenerative disease, affecting
10 million people worldwide. Neuroinflammation is one of the major pathologic processes in …
10 million people worldwide. Neuroinflammation is one of the major pathologic processes in …
[HTML][HTML] The intranigral infusion of human-alpha synuclein oligomers induces a cognitive impairment in rats associated with changes in neuronal firing and …
MF Palmas, M Etzi, A Pisanu, C Camoglio… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms
besides classical motor impairments, including cognitive disturbances. Recent studies in the …
besides classical motor impairments, including cognitive disturbances. Recent studies in the …