Dissecting the relationship between neuropsychiatric and neurodegenerative disorders

R Gupta, D Advani, D Yadav, RK Ambasta… - Molecular …, 2023 - Springer
Neurodegenerative diseases (NDDs) and neuropsychiatric disorders (NPDs) are two
common causes of death in elderly people, which includes progressive neuronal cell death …

Brain alarm by self-extracellular nucleic acids: From neuroinflammation to neurodegeneration

R Kunze, S Fischer, HH Marti, KT Preissner - Journal of biomedical …, 2023 - Springer
Neurological disorders such as stroke, multiple sclerosis, as well as the neurodegenerative
diseases Parkinson's or Alzheimer's disease are accompanied or even powered by danger …

Vortioxetine ameliorates experimental autoimmune encephalomyelitis model of multiple sclerosis in mice via activation of PI3K/Akt/CREB/BDNF cascade and …

MS Shafiek, RY Mekky, NN Nassar… - European Journal of …, 2024 - Elsevier
Multiple sclerosis (MS) is a chronic condition characterized by immune cell infiltration and
cytokine overproduction that led to myelin sheath inflammatory assaults, thus causing …

TLR2 deficiency is beneficial at the late phase in MPTP-induced Parkinson'disease mice

Y He, J Zhao, H Dong, X Zhang, Y Duan, Y Ma, M Yu… - Life Sciences, 2023 - Elsevier
Aims Parkinson's disease (PD) is a progressive neurodegenerative disorder. The etiology of
PD is still elusive but neuroinflammation is proved to be an important contributor. Toll-like …

Time-and Region-specific Effect of Vortioxetine on Central LPS-induced Transcriptional Regulation of NLRP3 Inflammasome

M Ciani, G Rigillo, C Benatti, L Pani… - Current …, 2025 - benthamdirect.com
Background Inflammasome overactivation, multiprotein complexes that trigger inflammatory
responses, plays a critical role in Major Depressive Disorder (MDD) pathogenesis and …

[HTML][HTML] Vortioxetine improves depressive symptoms and cognition in Parkinson's disease patients with major depression: an open-label prospective study

D Santos García, MG Alonso Losada… - Brain Sciences, 2022 - mdpi.com
Depression is frequent in Parkinson's disease (PD) patients, but the evidence for many
antidepressant agents to treat it in PD is insufficient. The aim of the present prospective open …

Cajanus cajan (L) Millsp seeds extract prevents rotenone-induced motor-and non-motor features of Parkinson disease in mice: Insight into mechanisms of …

TG Olubodun-Obadun, IO Ishola, OR Folarin… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Cajanus cajan (L) Millsp (Fabaceae) seed decoction is
used by traditional healers in Nigeria as nerve tonic, hence, could be beneficial in the …

Vortioxetine improved negative and cognitive symptoms of schizophrenia in subchronic MK-801 model in rats

NM Bozkurt, G Unal - Behavioural Brain Research, 2023 - Elsevier
Schizophrenia is a devastating psychiatric disorder with complex symptoms and
neurobiology. Serotonergic dysregulation is known to contribute to the pathogenesis of …

MicroRNA-gene regulatory network of TLR signaling in neuroinflammation-induced Parkinson's disease: a bioinformatics approach

G Singh, DK Khatri - Network Modeling Analysis in Health Informatics and …, 2024 - Springer
Parkinson's disease (PD) is the second-most common neurodegenerative disease, affecting
10 million people worldwide. Neuroinflammation is one of the major pathologic processes in …

[HTML][HTML] The intranigral infusion of human-alpha synuclein oligomers induces a cognitive impairment in rats associated with changes in neuronal firing and …

MF Palmas, M Etzi, A Pisanu, C Camoglio… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is a complex pathology causing a plethora of non-motor symptoms
besides classical motor impairments, including cognitive disturbances. Recent studies in the …