The role of BCL-2 family proteins in regulating apoptosis and cancer therapy

S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …

Modulating nitric oxide: implications for cytotoxicity and cytoprotection

I Belenichev, O Popazova, N Bukhtiyarova… - Antioxidants, 2024 - mdpi.com
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …

[HTML][HTML] Types of cell death from a molecular perspective

F Hajibabaie, N Abedpoor, P Mohamadynejad - Biology, 2023 - mdpi.com
Simple Summary Inflammation and free radicals can stimulate cell self-destruction.
Inflammation and cell death are vital aspects of most diseases. Accumulation of cell damage …

Anticancer potential of natural chalcones: in vitro and in vivo evidence

R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight

M Waseem, BD Wang - International journal of molecular sciences, 2023 - mdpi.com
Cancer has been progressively a major global health concern. With this develo** global
concern, cancer determent is one of the most significant public health challenges of this era …

TET3-overexpressing macrophages promote endometriosis

H Lv, B Liu, Y Dai, F Li, S Bellone, Y Zhou… - The Journal of Clinical …, 2024 - jci.org
Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of
reproductive-age women worldwide with no cure. While macrophages have been …

[HTML][HTML] Molecular mechanisms of autophagy in cancer development, progression, and therapy

VAM Vitto, S Bianchin, AA Zolondick, G Pellielo… - Biomedicines, 2022 - mdpi.com
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …

Mitochondrial signaling pathways and their role in cancer drug resistance

A Sharma, T Virmani, G Kumar, A Sharma, R Virmani… - Cellular …, 2024 - Elsevier
Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …

LRRK2 knockout confers resistance in HEK-293 cells to rotenone-induced oxidative stress, mitochondrial damage, and apoptosis

DA Quintero-Espinosa, S Sanchez-Hernandez… - International Journal of …, 2023 - mdpi.com
Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal
vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in …

Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis

M Qiu, L Cheng, J Xu, M **, W Yuan, Q Ge, K Zou… - Life Sciences, 2024 - Elsevier
Aims The main pathological features of osteoarthritis (OA) include the degeneration of
articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to …