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The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
S Qian, Z Wei, W Yang, J Huang, Y Yang… - Frontiers in …, 2022 - frontiersin.org
Apoptosis, as a very important biological process, is a response to developmental cues or
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
cellular stress. Impaired apoptosis plays a central role in the development of cancer and …
Modulating nitric oxide: implications for cytotoxicity and cytoprotection
Despite the significant progress in the fields of biology, physiology, molecular medicine, and
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
pharmacology; the designation of the properties of nitrogen monoxide in the regulation of life …
[HTML][HTML] Types of cell death from a molecular perspective
F Hajibabaie, N Abedpoor, P Mohamadynejad - Biology, 2023 - mdpi.com
Simple Summary Inflammation and free radicals can stimulate cell self-destruction.
Inflammation and cell death are vital aspects of most diseases. Accumulation of cell damage …
Inflammation and cell death are vital aspects of most diseases. Accumulation of cell damage …
Anticancer potential of natural chalcones: in vitro and in vivo evidence
R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …
decades. However, the discovery of new molecules with potential antitumor properties still …
Promising strategy of mPTP modulation in cancer therapy: an emerging progress and future insight
Cancer has been progressively a major global health concern. With this develo** global
concern, cancer determent is one of the most significant public health challenges of this era …
concern, cancer determent is one of the most significant public health challenges of this era …
TET3-overexpressing macrophages promote endometriosis
H Lv, B Liu, Y Dai, F Li, S Bellone, Y Zhou… - The Journal of Clinical …, 2024 - jci.org
Endometriosis is a debilitating, chronic inflammatory disease affecting approximately 10% of
reproductive-age women worldwide with no cure. While macrophages have been …
reproductive-age women worldwide with no cure. While macrophages have been …
[HTML][HTML] Molecular mechanisms of autophagy in cancer development, progression, and therapy
Autophagy is an evolutionarily conserved and tightly regulated process that plays an
important role in maintaining cellular homeostasis. It involves regulation of various genes …
important role in maintaining cellular homeostasis. It involves regulation of various genes …
Mitochondrial signaling pathways and their role in cancer drug resistance
Mitochondria, traditionally known as cellular powerhouses, now emerge as critical signaling
centers influencing cancer progression and drug resistance. The review highlights the role …
centers influencing cancer progression and drug resistance. The review highlights the role …
LRRK2 knockout confers resistance in HEK-293 cells to rotenone-induced oxidative stress, mitochondrial damage, and apoptosis
DA Quintero-Espinosa, S Sanchez-Hernandez… - International Journal of …, 2023 - mdpi.com
Leucine-rich repeat kinase 2 (LRRK2) has been linked to dopaminergic neuronal
vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in …
vulnerability to oxidative stress (OS), mitochondrial impairment, and increased cell death in …
Liquiritin reduces chondrocyte apoptosis through P53/PUMA signaling pathway to alleviate osteoarthritis
M Qiu, L Cheng, J Xu, M **, W Yuan, Q Ge, K Zou… - Life Sciences, 2024 - Elsevier
Aims The main pathological features of osteoarthritis (OA) include the degeneration of
articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to …
articular cartilage and a decrease in matrix synthesis. Chondrocytes, which contribute to …