Research on astronaut health and model organisms have revealed six features of
spaceflight biology that guide our current understanding of fundamental molecular changes …

On Earth, humans are subjected to a gravitational force that has been an important
determinant in human evolution and function. During spaceflight, astronauts are subjected to …

Spaceflight is known to impose changes on human physiology with unknown molecular
etiologies. To reveal these causes, we used a multi-omics, systems biology analytical …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Skeletal muscles underpin myriad human activities, maintaining an intricate balance
between protein synthesis and degradation crucial to muscle mass preservation …

The impact of spaceflight on the immune system has been investigated extensively during
spaceflight missions and in model experiments conducted on Earth. Data suggest that the …

Human Space exploration has created new challenges and new opportunities for science.
Reaching beyond the Earth's surface has raised the issue of the importance of gravity for the …

Exposure to microgravity and ionizing radiation during spaceflight missions causes
excessive reactive oxygen species (ROS) production that contributes to cellular stress and …

During space missions, astronauts are faced with a variety of challenges that are unique to
spaceflight and that have been known to cause physiological changes in humans over a …

Mounting ambitions and capabilities for public and private, non-government sector crewed
space exploration bring with them an increasingly diverse set of space travelers, raising new …