Irisin's emerging role in Parkinson's disease research: A review from molecular mechanisms to therapeutic prospects

R Qiu, W Sun, Y Su, Z Sun, K Fan, Y Liang, X Lin… - Life Sciences, 2024 - Elsevier
Abstract Parkinson's disease (PD), a neurodegenerative disorder characterized by impaired
motor function, is typically treated with medications and surgery. However, recent studies …

The impact of physical exercise on neuroinflammation mechanism in Alzheimer's disease

J Hu, B Huang, K Chen - Frontiers in Aging Neuroscience, 2024 - frontiersin.org
Introduction Alzheimer's disease (AD), a major cause of dementia globally, imposes
significant societal and personal costs. This review explores the efficacy of physical exercise …

Pulmonary Flora‐Derived Lipopolysaccharide Mediates Lung‐Brain Axis through Activating Microglia Involved in Polystyrene Microplastic‐Induced Cognitive …

H Kang, D Huang, W Zhang, JY Wang, Z Liu… - Advanced …, 2024 - Wiley Online Library
Microplastics (MPs) have been detected in the atmospheric and the human respiratory
system, indicating that the respiratory tract is a significant exposure route for MPs. However …

Ganoderma Lucidum polysaccharide peptide (GL-PP2): A potential therapeutic agent against sepsis-induced organ injury by modulating Nrf2/NF-κB pathways

T Yang, H Fang, D Lin, S Yang, H Luo, L Wang… - International Journal of …, 2025 - Elsevier
Sepsis, characterized by a severe immune response to infection, remains a leading cause of
mortality, with few effective strategies to prevent organ damage. Targeting inflammation …

[HTML][HTML] Lycopene alleviates age-related cognitive deficit via activating liver-brain fibroblast growth factor-21 signalling

J Wang, L Li, L Li, Y Shen, F Qiu - Redox Biology, 2024 - Elsevier
Brain function is linked with many peripheral tissues, including the liver, where hepatic
fibroblast growth factor 21 (FGF21) mediates communication between the liver and brain …

Gallic acid ameliorates LPS-induced memory decline by modulating NF-κB, TNF-α, and Caspase 3 gene expression and attenuating oxidative stress and neuronal …

M Dastan, Z Rajaei, M Sharifi, H Salehi - Metabolic Brain Disease, 2024 - Springer
Neuroinflammation and apoptosis play critical roles in the pathogenesis of Alzheimer's
disease (AD), which is responsible for most cases of dementia in the elderly people. Gallic …

Levosimendan and Dobutamin Attenuate LPS-Induced Inflammation in Microglia by Inhibiting the NF-κB Pathway and NLRP3 Inflammasome Activation via Nrf2/HO-1 …

F Mannino, V Urzì Brancati, R Lauro, I Pirrotta… - Biomedicines, 2024 - mdpi.com
Hypovolemic shock is a circulatory failure, due to a loss in the effective circulating blood
volume, that causes tissue hypoperfusion and hypoxia. This condition stimulates reactive …

Swimming exercise alleviates pathological bone features in curdlan-injected SKG mice by inducing irisin expression

SH Lee, B Nam, J Youn, KH Lee, S Jo - Life Sciences, 2024 - Elsevier
This study assessed the therapeutic potential of swimming exercise in the curdlan-injected
SKG mouse model and investigated the modulatory effects of irisin on inflammation. Curdlan …

Bibliometric Analysis of Neuroinflammation and Postoperative Cognitive Dysfunction

Z Chen, Z Zuo, Y Zhang, G Shan, L Zhang… - Brain and …, 2025 - Wiley Online Library
Background The occurrence and development of postoperative cognitive dysfunction
(POCD) are closely linked to neuroinflammation. This bibliometric analysis aims to provide …

TRIM55 aggravates cardiomyocyte apoptosis after myocardial infarction via modulation of the Nrf2/HO-1 pathway

Y Bu, Y Liu, M Liu, C Yan, J Wang, H Wu… - Basic to Translational …, 2024 - jacc.org
Summary Tripartite motif-containing 55 (Trim55) is mainly expressed in myocardium and
skeletal muscle, which plays an important role in promoting the embryonic development of …