Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Microglia are resident macrophages in the brain that emerge in early development and
respond to the local environment by altering their molecular and phenotypic states …

Microglia have emerged as important players in brain aging and pathology. To understand
how genetic risk for neurological and psychiatric disorders is related to microglial function …

HIV persistence in the CNS despite antiretroviral therapy may cause neurological disorders
and poses a critical challenge for HIV cure. Understanding the pathobiology of HIV-infected …

Emerging evidence suggests that the meningeal compartment plays instrumental roles in
various neurological disorders, however, we still lack fundamental knowledge about …

Background Amongst risk alleles associated with late-onset Alzheimer's disease (AD), those
that converged on the regulation of microglia activity have emerged as central to disease …

Microglial-derived inflammation has been linked to a broad range of neurodegenerative and
neuropsychiatric conditions, including amyotrophic lateral sclerosis (ALS). Using single-cell …

Microglia serve critical remodeling roles that shape the develo** nervous system,
responding to the changing neural environment with phagocytosis or soluble factor …

Background Microglia are tissue resident macrophages with a wide range of critically
important functions in central nervous system development and homeostasis. Method In this …