Ferrocene is an important structural core in bioorganometallic chemistry because of its
inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are …

Artemisinin and its derivatives are widely used throughout the world. The mechanism of
action of these compounds appears to involve the heme-mediated decomposition of the …

Experimenta naturae, like the glucose-6-phosphate dehydrogenase deficiency, indicate that
malaria parasites are highly susceptible to alterations in the redox equilibrium. This offers a …

Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Infectious diseases like malaria, tuberculosis or HIV are among the leading causes of death
worldwide according to WHO estimations. Nevertheless, the fight against infectious diseases …

Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are
currently our major hope in the fight against drug-resistant malaria. Rational drug design …

The artemisinins are the most potent and rapidly acting antimalarial drugs. In response to
the global threat of multidrug-resistant malaria, they are now widely used in combination …

Understanding the mode of action of and mechanism of resistance to drugs is central to
optimising their use, and discovering new therapeutics with novel targets. We have limited …

Malaria has been teasing human populations from a long time. Presently, several classes of
antimalarial drugs are available in market, but the issues of toxicity, lower efficacy and the …

The artemisinin derivatives, dihydroartemisinin (DHA), artesunate, atemether and arteether,
are currently used for treatment of malaria in artemisinin combination therapies (ACT) with …