Melatonin: a versatile protector against oxidative DNA damage
Oxidative damage to DNA has important implications for human health and has been
identified as a key factor in the onset and development of numerous diseases. Thus, it is …
identified as a key factor in the onset and development of numerous diseases. Thus, it is …
Mechanisms of free radical-induced damage to DNA
Endogenous and exogenous sources cause free radical-induced DNA damage in living
organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the …
organisms by a variety of mechanisms. The highly reactive hydroxyl radical reacts with the …
Oxidatively generated base damage to cellular DNA
Search for the formation of oxidatively base damage in cellular DNA has been a matter of
debate for more than 40years due to the lack of accurate methods for the measurement of …
debate for more than 40years due to the lack of accurate methods for the measurement of …
Oxidatively induced DNA damage and its repair in cancer
Oxidatively induced DNA damage is caused in living organisms by endogenous and
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
exogenous reactive species. DNA lesions resulting from this type of damage are mutagenic …
Oxidatively induced DNA damage: mechanisms, repair and disease
Endogenous and exogenous sources cause oxidatively induced DNA damage in living
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …
organisms by a variety of mechanisms. The resulting DNA lesions are mutagenic and …
Occurrence, biological consequences, and human health relevance of oxidative stress-induced DNA damage
A variety of endogenous and exogenous agents can induce DNA damage and lead to
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
genomic instability. Reactive oxygen species (ROS), an important class of DNA damaging …
DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans
Hazardous chemicals in the environment and diet or their electrophilic metabolites can form
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In …
Mutagenesis at methylated CpG sequences
Methylcytosine in DNA is genetically unstable. Methylated CpG (mCpG) sequences
frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in …
frequently undergo mutation resulting in a general depletion of this dinucleotide sequence in …
Mass spectrometry for the assessment of the occurrence and biological consequences of DNA adducts
Exogenous and endogenous sources of chemical species can react, directly or after
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
metabolic activation, with DNA to yield DNA adducts. If not repaired, DNA adducts may …
Bulky DNA lesions induced by reactive oxygen species
The integrity of the human genome is frequently challenged by endogenous and exogenous
agents, and reactive oxygen species (ROS) constitute the major endogenous source of DNA …
agents, and reactive oxygen species (ROS) constitute the major endogenous source of DNA …