Type 2 diabetes mellitus (T2DM) continues to be a substantial medical problem due to its
increasing global prevalence and because chronic hyperglycemic states are closely linked …

In addition to their bioenergetic intracellular function, several classical metabolites act as
extracellular signaling molecules activating cell-surface G-protein-coupled receptors …

There are at least two types of cannabinoid receptors (CB 1 and CB 2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ 9 …

Diabetes, a disease in which the body does not produce or use insulin properly, is a serious
global health problem,,. Gut polypeptides secreted in response to food intake, such as …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

Obesity is accompanied by the activation of low-grade inflammatory activity in metabolically
relevant tissues. Studies have shown that obesity-associated insulin resistance results from …

The endogenous lipid signaling agent oleoylethanolamide (OEA) has recently been
described as a peripherally acting agent that reduces food intake and body weight gain in …

Understanding differences in the repertoire of orthologous gene pairs is vital for
interpretation of pharmacological and physiological experiments if conclusions are …

The superfamily of G-protein–coupled receptors (GPCRs) is one of the largest and most
studied families of proteins. We created Hidden Markov Models derived from sorted groups …

Fatty acids (FAs) are typically associated with structural and metabolic roles, as they can be
stored as triglycerides, degraded by β-oxidation or used in phospholipids' synthesis, the …