Chediak-higashi syndrome

J Kaplan, I De Domenico… - Current opinion in …, 2008 - journals.lww.com
Although CHS is a rare disease, the Chediak-like family of proteins is providing insight into
the regulation of vesicle trafficking. Understanding the basic mechanisms that govern vesicle …

Epstein-Barr virus and human diseases: recent advances in diagnosis

M Okano, GM Thiele, JR Davis… - Clinical microbiology …, 1988 - journals.asm.org
Since the discovery of Epstein-Barr virus (EBV) from a cultured Burkitt's lymphoma cell line
in 1964, the virus has been associated with Burkitt's lymphoma, nasopharyngeal carcinoma …

The immune response to primary EBV infection: a role for natural killer cells

H Williams, K McAulay, KF Macsween… - British journal of …, 2005 - Wiley Online Library
The role of antigen‐specific CD3+ CD8+ cytotoxic T cells in the control of primary Epstein–
Barr Virus (EBV) infection is well established. However, time is required for the antigen …

Analysis of the lysosomal storage disease Chediak–Higashi syndrome

D McVey Ward, GM Griffiths, JC Stinchcombe, J Kaplan - Traffic, 2000 - Wiley Online Library
Chediak–Higashi syndrome (CHS) is a rare autosomal recessive disorder of human, mouse
(beige) and other mammalian species. The same genetic defect was found to result in the …

Chediak—Higashi Syndrome

Y Barak, E Nir - Journal of Pediatric Hematology/Oncology, 1987 - journals.lww.com
The use of cytochemical, electron microscopic, immunofluorescent, and tissue culture
techniques has led to important advances in our understanding of the mechanisms …

Genetic Defects in Chediak–Higashi Syndrome and the beige Mouse

RA Spritz - Journal of clinical immunology, 1998 - Springer
Chediak–Higashi syndrome (CHS) is a rare, autosomal recessive, multisystem disorder in
which severe immune deficits are accompanied by abnormalities of pigmentation, blood …

LYST affects lysosome size and quantity, but not trafficking or degradation through autophagy or endocytosis

P Holland, ML Torgersen, K Sandvig, A Simonsen - Traffic, 2014 - Wiley Online Library
Mutations in the large BEACH domain‐containing protein LYST causes Chediak–Higashi
syndrome. The diagnostic hallmark is enlarged lysosomes and lysosome‐related organelles …

The storage pool deficiency in platelets from humans with the Chédiak‐Higashi syndrome: study of six patients

R Apitz‐Castro, MR Cruz, E Ledezma… - British journal of …, 1985 - Wiley Online Library
Functional and biochemical studies of platelets from human Chédiak‐Higashi syndrome
(CHS) are scarce and/or incomplete. In the present report, the aggregation response to a …

A review of Epstein-Barr virus infection in patients with immunodeficiency disorders

M Okano, TG Gross - The American journal of the medical sciences, 2000 - Elsevier
ABSTRACT Epstein-Barr virus (EBV), one of 8 known human herpesviruses, infects the vast
majority of mankind and infections are generally subclinical. However, EBV infection has …

Advanced therapeutic and prophylactic strategies for Epstein–Barr virus infection in immunocompromised patients

M Okano, TG Gross - Expert Review of Anti-Infective Therapy, 2007 - Taylor & Francis
Epstein–Barr virus (EBV) is an ubiquitous human herpesvirus. Primary infection is generally
subclinical but in certain circumstances, such as in patients with either hereditary or …