Recent advances in epilepsy

M Manford - Journal of neurology, 2017 - Springer
This paper reviews advances in epilepsy in recent years with an emphasis on therapeutics
and underlying mechanisms, including status epilepticus, drug and surgical treatments …

Idiopathic generalized epilepsy: misunderstandings, challenges, and opportunities

O Devinsky, C Elder, S Sivathamboo, IE Scheffer… - Neurology, 2024 - neurology.org
The idiopathic generalized epilepsies (IGE) make up a fifth of all epilepsies, but< 1% of
epilepsy research. This skew reflects misperceptions: diagnosis is straightforward …

Focal abnormalities in idiopathic generalized epilepsy: a critical review of the literature

U Seneviratne, M Cook, W D'souza - Epilepsia, 2014 - Wiley Online Library
Conventionally, epilepsy is dichotomized into distinct “focal” and “generalized” categories.
However, many studies have reported so‐called focal features among patients with …

[HTML][HTML] Recent advances in neuroimaging of epilepsy

AM Goodman, JP Szaflarski - Neurotherapeutics, 2021 - Elsevier
Human neuroimaging has had a major impact on the biological understanding of epilepsy
and the relationship between pathophysiology, seizure management, and outcomes. This …

Clinical and EEG factors associated with antiseizure medication resistance in idiopathic generalized epilepsy

BK Kamitaki, M Janmohamed, P Kandula, C Elder… - …, 2022 - Wiley Online Library
Objective We sought to determine which combination of clinical and
electroencephalography (EEG) characteristics differentiate between an antiseizure …

Photosensitivity in generalized epilepsies

S Poleon, JP Szaflarski - Epilepsy & Behavior, 2017 - Elsevier
Photosensitivity, which is the hallmark of photosensitive epilepsy (PSE), is described as an
abnormal EEG response to visual stimuli known as a photoparoxysmal response (PPR). The …

Resistance to valproic acid as predictor of treatment resistance in genetic generalized epilepsies

J Gesche, M Khanevski, C Solberg, CP Beier - Epilepsia, 2017 - Wiley Online Library
This study aimed at defining clinical predictors of drug resistance in adults with genetic
generalized epilepsy (GGE) who were treated with a broad spectrum of antiepileptic drugs …

Neuroimaging in epilepsy

EH Middlebrooks, L Ver Hoef, JP Szaflarski - Current neurology and …, 2017 - Springer
In recent years, the field of neuroimaging has undergone dramatic development.
Specifically, of importance for clinicians and researchers managing patients with epilepsies …

Methods and utility of EEG-fMRI in epilepsy

LA van Graan, L Lemieux… - Quantitative imaging in …, 2015 - pmc.ncbi.nlm.nih.gov
Brain activity data in general and more specifically in epilepsy can be represented as a
matrix that includes measures of electrophysiology, anatomy and behaviour. Each of these …

Drug resistance in idiopathic generalized epilepsies: Evidence and concepts

J Gesche, CP Beier - Epilepsia, 2022 - Wiley Online Library
Abstract Although approximately 10%–15% of patients with idiopathic generalized epilepsy
(IGE)/genetic generalized epilepsy remain drug‐resistant, there is no consensus or …