Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Chili peppers are the major source of nature capsaicinoids, which consist of capsaicin,
dihydrocapsaicin, nordihydrocapsaicin, homodihydrocapsaicin, and homocapsaicin, etc …

The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Pharmacological management of severe chronic pain is difficult to achieve with currently
available analgesic drugs, and remains a large unmet therapeutic need. The synthetic …

The calcium channel antagonists are a mature group of drugs directed at cardiovascular
diseases including hypertension, angina, peripheral vascular disorders and some …

Many known painkillers are not always effective in the therapy of chronic neuropathic pain
manifested by hyperalgesia and tactile allodynia. The mechanisms underlying neuropathic …

Neuropathic pain affects more than one million people across the globe. The quality of life of
people suffering from neuropathic pain has been considerably declining due to the …

Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in
primary afferent neurons. N-type calcium channels are localized to synaptic nerve terminals …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Pain is a complex multidimensional concept that facilitates the initiation of the signaling
cascade in response to any noxious stimuli. Action potential generation in the peripheral …