Anti-apoptotic proteins in the autophagic world: an update on functions of XIAP, Survivin, and BRUCE
X-linked inhibitor of apoptosis protein (XIAP), survivin, and BRUCE are members of the
inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase …
inhibitor-of-apoptosis protein (IAP) family known for their inhibitory effects on caspase …
Survivin as a novel target protein for reducing the proliferation of cancer cells
D Li, C Hu, H Li - Biomedical reports, 2018 - spandidos-publications.com
Survivin, also known as baculoviral inhibitor of apoptosis repeat‑containing 5, is a novel
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …
member of the inhibitor of apoptosis protein family. Survivin is highly expressed in tumors …
BIRC5/Survivin is a novel ATG12–ATG5 conjugate interactor and an autophagy-induced DNA damage suppressor in human cancer and mouse embryonic fibroblast …
ABSTRACT BIRC5/Survivin is known as a dual cellular functions protein that directly
regulates both apoptosis and mitosis in embryonic cells during embryogenesis and in …
regulates both apoptosis and mitosis in embryonic cells during embryogenesis and in …
Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS
H Liu, L You, J Wu, M Zhao, R Guo… - Journal of Leucocyte …, 2020 - academic.oup.com
Berberine (BBR) is an isoquinoline alkaloid extracted from several commonly used Chinese
herbs. Our previous studies demonstrated BBR-mediated alleviation of lung injury due to …
herbs. Our previous studies demonstrated BBR-mediated alleviation of lung injury due to …
Berberine alleviates ox-LDL induced inflammatory factors by up-regulation of autophagy via AMPK/mTOR signaling pathway
X Fan, J Wang, J Hou, C Lin, A Bensoussan… - Journal of translational …, 2015 - Springer
Background Inflammation induced by oxidized low-density lipoprotein (ox-LDL) plays an
important role in the pathogenesis of atherosclerosis. Recently, roles of autophagy against …
important role in the pathogenesis of atherosclerosis. Recently, roles of autophagy against …
Discovery of a small molecule targeting ULK1-modulated cell death of triple negative breast cancer in vitro and in vivo
L Zhang, L Fu, S Zhang, J Zhang, Y Zhao, Y Zheng… - Chemical …, 2017 - pubs.rsc.org
UNC-51-like kinase 1 (ULK1) is well-known to initiate autophagy, and the downregulation of
ULK1 has been found in most breast cancer tissues. Thus, the activation of ULK1-modulated …
ULK1 has been found in most breast cancer tissues. Thus, the activation of ULK1-modulated …
Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice
S Shao, CB Xu, CJ Chen, GN Shi, QL Guo… - Journal of …, 2021 - Springer
Background Chronic neuropathic pain is a frequent sequel to peripheral nerve injury and
maladaptive nervous system function. Divanillyl sulfone (DS), a novel structural derivative of …
maladaptive nervous system function. Divanillyl sulfone (DS), a novel structural derivative of …
Cell survival and cell death at the intersection of autophagy and apoptosis: Implications for current and future cancer therapeutics
N Bata, NDP Cosford - ACS pharmacology & translational science, 2021 - ACS Publications
Autophagy and apoptosis are functionally distinct mechanisms for cytoplasmic and cellular
turnover. While these two pathways are distinct, they can also regulate each other, and …
turnover. While these two pathways are distinct, they can also regulate each other, and …
Targeting survivin for cancer therapy: Strategies, small molecule inhibitors and vaccine based therapeutics in development
Survivin is a member of the family of inhibitors of apoptosis proteins (IAPs). It is involved in
the normal mitotic process and acts as an anti-apoptotic molecule. While terminally …
the normal mitotic process and acts as an anti-apoptotic molecule. While terminally …
HTLV-1 bZIP factor RNA and protein impart distinct functions on T-cell proliferation and survival
Infection of T cells with human T-cell leukemia virus type-1 (HTLV-1) induces clonal
proliferation and is closely associated with the onset of adult T-cell leukemia-lymphoma …
proliferation and is closely associated with the onset of adult T-cell leukemia-lymphoma …