Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

The spinal dorsal horn receives input from primary afferent axons, which terminate in a
modality-specific fashion in different laminae. The incoming somatosensory information is …

The two amino acids GABA and glycine mediate fast inhibitory neurotransmission in different
CNS areas and serve pivotal roles in the spinal sensory processing. Under healthy …

GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and
GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed …

The diversity of GABAA receptor (GABAAR) subunits and the numerous configurations
during subunit assembly give rise to a variety of receptors with different functional properties …

Rationale Neurosteroids are steroids synthesized within the brain with rapid effects on
neuronal excitability. Allopregnanolone, allotetrahydrodeoxycorticosterone, and …

Neuroactive steroids synthesized in neuronal tissue, referred to as neurosteroids, are
implicated in proliferation, differentiation, activity and survival of nerve cells. Neurosteroids …

Pain is a percept of critical importance to our daily survival. In most cases, it serves both an
adaptive function by hel** us respond appropriately in a potentially hostile environment …

Sensory information transmitted to the spinal cord dorsal horn is modulated by a complex
network of excitatory and inhibitory interneurons. The two main inhibitory transmitters, GABA …

Glycinergic neurotransmission has long been known for its role in spinal motor control.
During the last two decades, additional functions have become increasingly recognized …