Aims Although debates over the efficacy of oral naltrexone and acamprosate in treating
alcohol use disorders tend to focus on their global efficacy relative to placebo or their …

Alcohol use disorders (AUD) are defined as alcohol abuse and alcohol dependence, which
create large problems both for society and for the drinkers themselves. To date, no …

A Heck–Matsuda process for the synthesis of the otherwise difficult to access compounds, β‐
arylethenesulfonyl fluorides, is described. Ethenesulfonyl fluoride (ie, vinylsulfonyl fluoride …

Objective Empirical evidence has only weakly supported antidepressant treatment for
patients with co-occurring depression and alcohol dependence. While some studies have …

Alcohol dependence is a disease that impacts millions of individuals worldwide. There has
been some progress with pharmacotherapy for alcohol-dependent individuals; however …

Repeated exposure to drugs of abuse produces long‐term molecular and neurochemical
changes that may explain the core features of addiction, such as the compulsive seeking …

Abstract The Sulfur (VI) Fluoride Exchange reaction (SuFEx) developed by Sharpless and co-
workers in 2014, is a promising new click reaction that rests on the extraordinary elevated …

The development of alcohol dependence is posited to involve numerous changes in brain
chemistry (ie, neurotransmission) that lead to physiological signs of withdrawal upon …

Importance Alcohol use disorder is one of the leading causes of disability worldwide. While
effective pharmacological treatments exist, they are efficacious only in certain individuals …

Abstinence from alcohol has been the prevailing treatment goal for individuals with alcohol
dependence (AD) within the context of specialty alcohol treatment. Yet, alcohol use has …