The functions of the neuronal microtubule-associated protein Tau in the central nervous
system are regulated by manifold posttranslational modifications at more than 50 sites. Tau …

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Formation of membrane-less organelles via liquid-liquid phase separation is one way cells
meet the biological requirement for spatiotemporal regulation of cellular components and …

The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the
mechanism underlying tau-associated neural damage remains unclear. Here, we show that …

Tau protein plays a critical role in the assembly, stabilization, and modulation of
microtubules, which are important for the normal function of neurons and the brain. In …

The progressive deposition of misfolded hyperphosphorylated tau is a pathological hallmark
of tauopathies, including Alzheimer's disease. However, the underlying molecular …

Determining the functional relationship between Tau phosphorylation and aggregation has
proven a challenge owing to the multiple potential phosphorylation sites and their clustering …

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …

Amyloid-β (Aβ) and tau proteins currently represent the two most promising targets to treat
Alzheimer's disease. The most extensively developed method to treat the pathologic forms of …