Entry of bacteria into host cells is an important virulence mechanism. Through peptidoglycan
recognition, the nucleotide-binding oligomerization domain (NOD) proteins NOD1 and …

It has been long recognized that NOD1 and NOD2 are critical players in the host immune
response, primarily by their sensing bacterial peptidoglycan‐conserved motifs. Significant …

NOD1 and NOD2 are related intracellular sensors of bacterial peptidoglycan and belong to
the Nod-like receptor (NLR) family of innate immune proteins that play fundamental and …

Sensing intracellular pathogens is a process mediated by innate immune cells that is crucial
for the induction of inflammatory processes and effective adaptive immune responses …

Type 1 diabetes (T1D) is an autoimmune disease that is triggered by both genetic and
environmental factors, resulting in the destruction of pancreatic β cells. The disruption of the …

Innate immune signaling and programmed cell death are intimately linked, and many
signaling pathways can regulate and induce both, transcription of inflammatory mediators or …

Inflammasomes are multimeric complexes of proteins that are assembled in the host cell
cytoplasm in response to specific stress signals or contamination of the cytoplasm by …

The innate immune system is composed of a wide repertoire of conserved pattern
recognition receptors (PRRs) able to trigger inflammation and host defense mechanisms in …

Background: The cytoplasmatic pattern recognition receptor, NOD2 (nucleotide-binding
oligomerization domain 2), belongs to the innate immune system and is among others …

Nod-like receptors (NLRs) have gained attention in recent years because of the ability of
some family members to assemble into a multimeric protein complex known as the …