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Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy
Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
Recent advances in the synthesis of indole and quinoline derivatives through cascade reactions
J Barluenga, F Rodríguez… - Chemistry–An Asian …, 2009 - Wiley Online Library
One right after the other: Cascade reactions represent an efficient method for accessing
highly functionalized final products from simple starting materials in a single synthetic …
highly functionalized final products from simple starting materials in a single synthetic …
Advances in the syntheses of quinoline and quinoline-annulated ring systems
S Madapa, Z Tusi, S Batra - Current Organic Chemistry, 2008 - ingentaconnect.com
Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …
Recent advances in research of natural and synthetic bioactive quinolines
PY Chung, ZX Bian, HY Pun, D Chan… - Future medicinal …, 2015 - Taylor & Francis
Many natural products that consist of quinoline core are found to be bioactive and the
versatility of quinoline and its derivatives have attracted great attention in the field of drug …
versatility of quinoline and its derivatives have attracted great attention in the field of drug …
Synthesis, structural characterization, DFT calculations, and molecular docking of a novel quinoline derivative
A novel quinoline derivative,(E)-N-phenyl-4-((quinoli-4-ylmethylene) amino) aniline (PQYA),
was synthesized using a previously reported approach with 80% yield. Single X-ray …
was synthesized using a previously reported approach with 80% yield. Single X-ray …
Iodine-catalyzed direct C–H alkenylation of azaheterocycle N-oxides with alkenes
Z Zhang, C Pi, H Tong, X Cui, Y Wu - Organic Letters, 2017 - ACS Publications
An efficient and regioselective alkenylation of azaheterocycle N-oxides with alkenes
catalyzed by iodine under metal-and external oxidant-free reaction conditions has been …
catalyzed by iodine under metal-and external oxidant-free reaction conditions has been …
[HTML][HTML] Structure-based design of new diclofenac: Physicochemical, spectral, molecular docking, dynamics simulation and ADMET studies
Diclofenac, a nonsteroidal anti-inflammatory drug, is commonly prescribed for the analgesic,
antipyretic and anti-inflammation treatment. It is effectively used in acute and chronic pain. It …
antipyretic and anti-inflammation treatment. It is effectively used in acute and chronic pain. It …
The synthesis and anticancer activity of 2-styrylquinoline derivatives. A p53 independent mechanism of action
A series of styrylquinolines was designed and synthesized based on the four main quinoline
scaffolds including oxine, chloroxine and quinolines substituted with a hydroxyl group or …
scaffolds including oxine, chloroxine and quinolines substituted with a hydroxyl group or …
A foundational theoreticalAl12E12(E = N, P) adsorption and quinolone docking study: cage–quinolone pairs, optics and possible therapeutic and diagnostic …
Abstract This combined Al12 E 12 (E= N, P) surface adsorption and docking study describes
the new possibility of prospective potential probing (photophysical/optical) and therapy …
the new possibility of prospective potential probing (photophysical/optical) and therapy …
Povarov-Type Reaction Using Methyl as New Input: Direct Synthesis of Substituted Quinolines by I2-Mediated Formal [3 + 2 + 1] Cycloaddition
A highly efficient molecular iodine mediated formal [3+ 2+ 1] cycloaddition reaction for the
direct synthesis of substituted quinolines from methyl ketones, arylamines, and styrenes is …
direct synthesis of substituted quinolines from methyl ketones, arylamines, and styrenes is …